Autoimmunity

Study G protein-coupled receptor signaling in cells

A major active metabolite of flurbiprofen

Concanavalin A belongs to the concanamycins, a family of macrolide antibiotics isolated from Streptomyces diastatochromogenes that are highly active and selective inhibitors of the vacuolar proton-ATPase (v-[H[+]]ATPase).

A metabolite of meloxicam

A racemate of Benpyrine, is a potent and orally active TNF-α inhibitor

NIBR0213 is an orally bioavailable, potent, and selective antagonist of sphingosine-1-phosphate receptor-1 (S1P1) with IC50 values of 2.5 and 2.0 nM for the hS1P1 in a Ca2+ mobilization assay and GTPγS assay, respectively.

BI605906 is a novel IKKβ inhibitor with an IC50 value of 380 nM when assayed at 0.1 mM ATP.

Cyclic di-GMP disodium is a cyclic dinucleotide signaling molecule synthesized by bacteria and is a STING agonist.

Ginsenoside CK, a secondary ginsenoside biotransformed from major ginsenosides, is more bioavailable and soluble than its parent ginsenosides and holds great significance.

Concanavalin ACon A, derived from Canavalia ensiformis beans, is a lectin protein (Mw 104 kDa).

Perfluorotridecanoic Acid (Perfluorinated Compound (PFC)) is a perfluorinated alkyl acid (PFAA) and a possible organic pollutant

Nigakinone is one of the most abundant alkaloids responsible for the major pharmacological activities of Kumu.

Histone H2B (21-35) is a peptide fragment of histone H2B that corresponds to amino acid residues 22-36 of the human histone H2B sequence.

Ramipril-d5 is intended for use as an internal standard for the quantification of ramipril by GC- or LC-MS.

N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine.

(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.

Feprazone is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor that is 10-fold selective for COX-2 over COX-1.

C-178 is a covalent inhibitor of STING.

Actarit is an orally active immunomodulator that reduces symptoms in animal models and clinical trials of rheumatoid arthritis.

Diflorasone is a corticosteroid with anti-inflammatory activity.

Isogarcinol is a polyprenylated benzophenone natural compound extracted from plants of the Garciniagenus. Isogarcinol is also an effective inhibitor of acetylcholinesterase (AChE; IC₅₀=1.13μM) and butyrylcholinesterase (BChE; IC₅₀=8.30μM).

20α-dihydro Prednisolone is a metabolite of prednisolone.

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.

Luteoloside is a flavonoid that has been found in many Chinese herbs with diverse biological activities.