GLPBio

Cyclomarin monomer-2

Catalog No.: GC79846Purity:>97.00%
COASDSData Sheet
Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1.

Products are for research use only. Not for human use. We do not sell to patients.

Cyclomarin monomer-2
1mgIn Stock
$168.00
1
5mgIn Stock
$421.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

Description

Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-2 binds to the Mtb ClpC1 protein with a K D of 4.0 nM. The MIC of Cyclomarin monomer-2 against the Mtb H37Rv standard strain is 3.1 μM. Cyclomarin monomer-2 can be used as a key intermediate in the development of Homo-BacPROTACs [1].

References:
[1]. Junk L, et al. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nat Commun. 2024 Mar 5;15(1):2005

Product Documents

Purity:>97.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C49H68N8O9
Molecular Weight
913.11
Solubility
DMSO: ≥ 100 mg/mL (109.52 mM)
Storage
Sealed storage, away from moisture and light, under nitrogen
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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