GLPBio

CYP3A/CYP450

CYP3A4 is an enzyme of cytochrome P450 superfamily found in human liver. It catalyzes the metabolism of endogenous and exogenous agents ( e.g. xenobiotics).

Products Related to CYP3A/CYP450(19)

  • GC10554 structure
    GC105543-Cyano-7-ethoxycoumarin
    CAS: 117620-77-6
    Purity: >98.00%

    Fluorescent P450 substrate

  • GC10762 structure
    GC107624β-hydroxy Cholesterol
    CAS: 17320-10-4
    Purity: >95.00%

    An endogenous marker for CYP3A4/5 activity

  • GC10778 structure
    GC10778DDMS
    CAS: 206052-03-1
    Purity: >98%

    CYP4A2 enzyme inhibitor

  • GC10886 structure
    GC10886Methoxyresorufin
    CAS: 5725-89-3
    Purity: >98%

    Methoxyresorufin (Methoxyresorufin) is a cytochrome P450 fluorometric substrate.

  • GC11731 structure
    GC117314-phenyl-1,2,3-Thiadiazole
    CAS: 25445-77-6
    Purity: >98%

    selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1)

  • GC11864 structure
    GC118646,7-dihydroxy Bergamottin
    CAS: 145414-76-2
    Purity: >98.00%

    potent inhibitor of CYP3A4

  • GC12211 structure
    GC12211Tienilic Acid
    CAS: 40180-04-9

    specific suicide substrate for CYP2C9 and CYP2C10

  • GC13079 structure
    GC13079Voriconazole
    CAS: 137234-62-9
    Purity: >99.50%

    Voriconazole is a potent competitive inhibitor of CYP2B6 (IC 50 =1.71μM), CYP2C9 (IC 50 =3.62μM), CYP2C19 (IC 50 =5.25μM), and CYP3A (IC 50 =2.90μM).

  • GC13784 structure
    GC137847-Ethoxyresorufin
    CAS: 5725-91-7
    Purity: >98.00%

    Specific subtrate of CYP1A

  • GC14269 structure
    GC14269Cobicistat (GS-9350)
    CAS: 1004316-88-4
    Purity: >98.00%

    An inhibitor of CYP3A

  • GC14618 structure
    GC14618PPOH
    CAS: 206052-01-9
    Purity: >98%

    inhibitor of CYP epoxidase activity on arachadonic acid

  • GC14781 structure
    GC147811-Aminobenzotriazole (ABT)
    CAS: 1614-12-6
    Purity: >97.00%

    1-Aminobenzotriazole (ABT) is an orally active nonspecific and irreversible inhibitor of cytochrome P450 (CYP).

  • GC15445 structure
    GC15445TMS
    CAS: 24144-92-1
    Purity: >98.00%

    TMS (2,3′,4,5′-tetramethoxystilbene) is a specific and powerful CYP1B1 inhibitor, with an IC 50 value of 6±2nmol/L.

  • GC16073 structure
    GC16073Dronedarone
    CAS: 141626-36-0
    Purity: >99.50%

    An antiarrhythmic agent

  • GC16550 structure
    GC16550Diosmetin
    CAS: 520-34-3
    Purity: >99.50%

    CYP1A1 inhibitor

  • GC16754 structure
    GC16754Clarithromycin
    CAS: 81103-11-9
    Purity: >98.00%

    Clarithromycin is a macrolide antibiotic that functions by inhibiting bacterial protein synthesis. Clarithromycin binds to the 50S subunit of the bacterial ribosome, preventing peptide chain elongation and thereby suppressing bacterial growth.

  • GC16777 structure
    GC16777YM 511
    CAS: 148869-05-0
    Purity: >98%

    aromatase (CYP19) inhibitor

  • GC17552 structure
    GC17552Pentoxyresorufin
    CAS: 87687-03-4
    Purity: >98.00%

    Pentoxyresorufin (Pentoxyresorufin) is a Resazurin analogue.

  • GC14382 structure
    GC14382VT-464 R enantiomer
    Purity: >98%

    CYP17 lyase inhibitor