Metabolism
- Sterol Biosynthesis(26)
- PPAR(177)
- 5-alpha Reductase(8)
- 5-Lipoxygenase(11)
- Adenosine Deaminase(8)
- Aminopeptidase(10)
- C14ɑ demethylase(2)
- Carbonic Anhydrase(40)
- CETP(8)
- Cholesterol absorption(1)
- CPT1(2)
- CYP3A/CYP450(18)
- Dehydrogenase(37)
- DHFR(6)
- DGAT(7)
- Dopamine β-hydroxylase(10)
- Enolase(4)
- FAAH(31)
- Factor Xa(37)
- Ferroptosis(159)
- Folate Analogue(2)
- Glucokinase(15)
- HMG-CoA Reductase(33)
- HSP(69)
- IDO(40)
- KRAS-PDEδ(3)
- MAO(6)
- Neuronal Metabolism(8)
- Oxidative Phosphorylation(17)
- P450(110)
- PDE(211)
- Phospholipase(108)
- Procollagen C Proteinase(1)
- Saccharometabolism(1)
- SCD(16)
- SGLT(24)
- TPH(4)
- Transferase(21)
- ALP(1)
- Carbohydrates(18)
- Transaminase(1)
- Catalase(7)
- monooxygenase(1)
- PKM2(1)
- aldehyde dehydrogenase(1)
- Squalene synthase(1)
- Hydrolase(13)
- ornithine decarboxylase(1)
- Amino acid metabolism(3)
- phosphatases(92)
- Pyruvate kinase(6)
- Others(4)
- MGL(1)
- Galactosidase(1)
- 12-Lipoxygenase(1)
- Fatty Acid Synthase (FASN)(7)
- Dihydroorotate Dehydrogenase(11)
- Bile Acids & Microbiome(91)
- Bone Growth & Remodeling(34)
- Carbohydrate Metabolism(121)
- Cofactors & Vitamins(62)
- Dyslipidemias(71)
- Inborn Errors of Metabolism(78)
- Metabolic Syndrome(16)
- Necroptosis(9)
- Necrosis(15)
- Nutrient Sensing(11)
- Phosphodiesterase(27)
- Reproductive Biology(122)
- Thermogenesis(4)
- Prolyl Hydroxylation Enzymes(1)
- Biliary System(4)
- Metabolic Disease(4)
- Cat.No. Product Name Information
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GC68479
MMRi62
-
GC68460
PDE4B-IN-3
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GC68450
Hsp90-IN-17 hydrochloride
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GC68445
SCD1 inhibitor-3
-
GC68325
Roflumilast-d4 N-Oxide
-
GC68317
(3S,5R)-Fluvastatin-d6 sodium
-
GC68229
PDE5-IN-7
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GC68133
Palmatine hydroxide
-
GC68041
Pentoxifylline-d5
-
GC68034
Enoxaparin
-
GC68003
Cadisegliatin
-
GC67997
Aminopeptidase-IN-1
-
GC67967
Dovramilast
-
GC67933
LKY-047
-
GC67916
Palmitic acid-d4
-
GC67909
GSK2647544
-
GC67901
Glucokinase activator 3
-
GC67894
FASN-IN-5
-
GC67866
PPARδ/γ agonist 1 sodium
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GC67864
(R)-Irsenontrine
-
GC67714
DP00477
-
GC52513
Indolimine-214
A genotoxic gut microbiota metabolite
-
GC52504
Human Vitamin D Receptor Reporter Assay System
A nuclear receptor cell-based reporter assay
-
GC52497
Lactosylceramide (porcine RBC)
A sphingolipid
-
GC52496
Sulfatide (bovine) (sodium salt)
A mixture of isolated bovine sulfatides
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GC52493
Glucosylceramide (bovine buttermilk)
A sphingolipid
-
GC52492
Globotriaosylceramide (hydroxy) (porcine RBC)
A sphingolipid
-
GC52491
Globotriaosylceramide (non-hydroxy) (porcine RBC)
A sphingolipid
-
GC52467
Cell Death Screening Library
For screening a variety of cell death pathways
-
GC52462
Microbiome Metabolite Screening Library
For screening a variety of microbiome metabolites
-
GC52428
10-oxo-12(Z)-Octadecenoic Acid-d5
An internal standard for the quantification of 10-oxo-12(Z)-octadecenoic acid
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GC52421
(±)-10-hydroxy-12(Z)-Octadecenoic Acid-d5
An internal standard for the quantification of (±)-10-hydroxy-12(Z)-octadecenoic acid
-
GC52420
Drospirenone-13C3
An internal standard for the quantification of drospirenone
-
GC52413
5-Aminosalicylic Acid-d7
An internal standard for the quantification of 5-aminosalicylic acid
-
GC52409
BAM-22P (8-22) (human, mouse, rat, bovine) (trifluoroacetate salt)
A neuropeptide and MRGPRX1 agonist
-
GC52404
γ-Glu-Phe (trifluoroacetate salt)
A dipeptide with metabolism-altering activity
-
GC52400
γ-Glu-Ala (trifluoroacetate salt)
A dipeptide
-
GC52390
Spexin 1 (human, mouse, rat, bovine) (acetate)
An endogenous peptide and agonist of GAL2 and GAL3
-
GC52384
NFAT Inhibitor (cell-permeable) (trifluoroacetate salt)
A cell-permeable form of NFAT inhibitor
-
GC52376
BMP2-derived Peptide (trifluoroacetate salt)
A synthetic peptide
-
GC52361
AMARA Peptide (trifluoroacetate salt)
A peptide substrate for AMPK
-
GC52351
Citrullinated α-Enolase (R8 + R14) (1-19)-biotin Peptide
A biotinylated and citrullinated α-enolase peptide
-
GC52329
Betamethasone-d5
An internal standard for the quantification of betamethasone
-
GC52324
3-(3-Hydroxyphenyl)propionic Acid sulfate
A metabolite of certain phenols and glycosides
-
GC52323
L-Isoleucine-13C6
An internal standard for the quantification of L-isoleucine
-
GC52318
Oleic Acid-13C5
An internal standard for the quantification of oleic acid
-
GC52317
BCP-T.A.
A ferroptosis inducer
-
GC52315
GK241
An sPLA2 (Type IIA) inhibitor
-
GC52304
Perfluoroheptanoic Acid
A perfluoroalkyl substance
-
GC52290
(R)-HTS-3
An inhibitor of LPCAT3
-
GC52278
Creatine Phosphate (sodium salt hydrate)
A phosphorylated form of creatine
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GC52257
Perfluorohexanoic Acid
A perfluoroalkyl substance
-
GC52253
α-Enolase (1-19)-biotin Peptide
A biotinylated α-enolase peptide
-
GC52251
Imidacloprid Impurity 1
A potential impurity in commercial preparations of imidacloprid
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GC52231
Heptadecanoyl-L-carnitine-d3 (chloride)
An internal standard for the quantification of heptadecanoyl-L-carnitine
-
GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
An active metabolite of various polyphenols
-
GC52219
Heptadecanoyl-L-carnitine (chloride)
A long-chain acylcarnitine
-
GC52214
Nicotinamide riboside-d4 (triflate)
An internal standard for the quantification of nicotinamide riboside
-
GC67661
S-2E
S-2E is an orally active and noncompetitive HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. S-2E has an anti-hyperlipidemic action. S-2E has the potential for familial hypercholesterolemia and mixed hyperlipidemia research.
-
GC67211
BAPTA tetrapotassium
BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
-
GC66645
L-Adenosine
L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an Ki value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation.
-
GC66360
Girentuximab
Girentuximab (G250) is a chimeric monoclonal antibody that binds carbonic anhydrase IX (CAIX), a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC).
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GC66197
α-?Terpinyl acetate
α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM.
-
GC66059
YZ129
YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration.
-
GC66042
Enpp-1-IN-14
ENPP1-IN-2 is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.
-
GC66029
hCAI/II-IN-6
hCAI/II-IN-6 is an orally active human carbonic anhydrase (CA) inhibitor. hCAI/II-IN-6 selectively inhibits hCA II and hCA VII isoforms with Ki values of 220, 4.9, 6.5 and >50000 nM for hCA I, hCA II , hCA VII and hCA XII respectively. hCAI/II-IN-6 shows anticonvulsant activity and anti maximal electroshock (MES) activity in vivo. hCAI/II-IN-6 can be used for the research of epilepsy.
-
GC66015
IHVR-11029
IHVR-11029 is a small molecule inhibitor of ER α-glucosidases, with an EC50 of 0.09 μM.
-
GC66005
CVT-11127
CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer.
-
GC65925
TDP1 Inhibitor-1
TDP1 Inhibitor-1 is a potent Tyrosyl-DNA Phosphodiesterase 1 (TDP1) inhibitor with an IC50 of 7 μM.
-
GC65912
Asundexian
Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM.
-
GC65911
Irsenontrine
Irsenontrine (E2027) is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine can be used for the research of neurological diseases.
-
GC65895
IDO1-IN-19
IDO1-IN-19 (Compound 17) is a potent inhibitor of IDO1. IDO1-IN-19 has the potential for the research of cancer diseases.
-
GC65612
Acetazolamide sodium
Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities.
-
GC52194
Dimethylamino Parthenolide
-
GC52190
Imidazole Ketone Erastin
-
GC52189
Nomegestrol
Nomegestrol is a potent and orally available progestin, acts as a selective full progesterone receptor agonist, with a Kd of 5.44 nM for rat uterine progesterone receptor, and has moderate antiandrogenic activity and strong antiestrogenic activity.
-
GC52170
2-Nitroamino-2-imidazoline
-
GC52164
Cu-ATSP
Cu-ATSP, a potent inhibitor of ferroptotic cell death, is almost 20-fold more potent than CuATSM.
-
GC52159
N-methyl Tyramine (hydrochloride)
-
GC52149
306-O12B
-
GC52139
NG-497
-
GC52138
Pantoic Acid
-
GC52129
3-Amino-5-hydroxybenzoic Acid
-
GC52126
8-chloro Caffeine
-
GC52125
T-1095
T-1095 is a selective and orally active Na+-glucose cotransporter (SGLT) inhibitor with IC50s of 22.8 ?M and 2.3 ?M for human SGLT1 and SGLT2, respectively.
-
GC65595
3-Nitrocoumarin
3-Nitrocoumarin (3-NC) is a potent and selective Phospholipase C-γ (PLC-γ) inhibitor.
-
GC65549
Indisulam
Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15.
-
GC65517
4-(Trifluoromethyl)umbelliferone
4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes.
-
GC65499
IDO1/2-IN-1 hydrochloride
IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active.
-
GC65426
CM-675
CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively.
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GC65414
2-(Tetradecylthio)acetic acid
2-Tetradecylthio acetic acid is a pan-peroxisome proliferator activated receptor (pan-PPAR) activator.
-
GC65409
7-Methylcoumarin
7-Methylcoumarin, a coumarin, exhibits strong hepatoprotective activity and potent antioxidant effect.
-
GC65360
PDE10-IN-5
PDE10-IN-5 is a phosphodiesterase 10 (PDE 10) inhibitor, can be used for researching certain central nervous system (CNS) disorders.
-
GC65345
BI 653048
BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM.
-
GC65335
PTC299
PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies.
-
GC65318
BOLD-100
BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.
-
GC65302
SDZ-MKS 492
SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE).
-
GC65260
EDP-305
EDP-305 is an orally active, potent and selective farnesoid X receptor (FXR) agonist, with EC50 values of 34 nM (chimeric FXR in CHO cells) and 8 nM (full-length FXR in HEK cells).
-
GC65258
PDE10A-IN-2 hydrochloride
PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 2.8 nM.
-
GC65246
Deltasonamide 2
Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.