GLPBio

DBCO-NHCO-PEG4-amine TFA

Catalog No.: GC78796Purity:>96.50%
COASDSData Sheet
DBCO-NHCO-PEG4-amine TFA is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Products are for research use only. Not for human use. We do not sell to patients.

DBCO-NHCO-PEG4-amine TFA
5mgIn Stock
$69.00
1
10mgIn Stock
$109.00
1
25mgIn Stock
$219.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

DBCO-NHCO-PEG4-amine TFA is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine TFA is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC 50 s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

References:
[1]. Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15(5):2054-2059.

Product Documents

Purity:>96.50%Appearance:An oil
COASDSData Sheet

Chemical Properties

Molecular Formula
C31H38F3N3O8
Molecular Weight
637.64
Solubility
H2O: 50 mg/mL (78.41 mM; ultrasonic and warming and heat to 60°C)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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