DBCO-PEG2-amine is a click chemistry reagent [1]. DBCO-PEG2-amine has a strain-promoting alkyne group (DBCO), a hydrophilic polyethylene glycol (PEG2) chain, and a reactive amino terminus [1]. DBCO-PEG2-amine efficiently undergoes click reactions (SPAAC) with azide-modified molecules without the need for a copper catalyst [2]. DBCO-PEG2-amine is used in cell labeling, drug delivery, bioimaging, and other fields, and has good biocompatibility and reaction selectivity [3].
References:
[1]. An S, Fu L. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct 1; 36: 553-562.
[2]. Pringle TA, Knight JC. The effects of buffer, pH, and temperature upon SPAAC reaction rates. Organic & Biomolecular Chemistry. 2025; 23(10): 2432-2438.
[3]. Baker CJ, Smith SA, Morrissey JH. Diversification of polyphosphate end-labeling via bridging molecules. PLoS One. 2020 Aug 21; 15(8): e0237849.