11-Dehydrodexamethasone, Dexamethasone derivative, is a substrate for 11β-hydroxysteroid dehydrogenase ( 11β-HSD ) 1/2. 11-Dehydrodexamethasone undergoes conversion to Dexamethasone via reductive activity of 11β-HSD [1].
In Vitro, 11-Dehydrodexamethasone (20 ng; 10 min) acts as a substrate for both 11β-HSD1 (rat liver) and 11β-HSD2 (rat renal cortex, human kidney) isozymes, undergoing conversion to Dexamethasone with mean conversion rates of 65%, 53.5%, and 69% respectively in the tested tissue homogenates[1].
References:
[1]. Best R, et al. Dexamethasone and 11-dehydrodexamethasone as tools to investigate the isozymes of 11 beta-hydroxysteroid dehydrogenase in vitro and in vivo. J Endocrinol. 1997;153(1):41-48.
In Vitro, 11-Dehydrodexamethasone (20 ng; 10 min) acts as a substrate for both 11β-HSD1 (rat liver) and 11β-HSD2 (rat renal cortex, human kidney) isozymes, undergoing conversion to Dexamethasone with mean conversion rates of 65%, 53.5%, and 69% respectively in the tested tissue homogenates[1].
References:
[1]. Best R, et al. Dexamethasone and 11-dehydrodexamethasone as tools to investigate the isozymes of 11 beta-hydroxysteroid dehydrogenase in vitro and in vivo. J Endocrinol. 1997;153(1):41-48.