4-Arm-PEG10000-DBCO is a four-armed PEG derivative. The core structure of 4-Arm-PEG10000-DBCO consists of four PEG chains, each modified at the end with a diphenylcyclooctyne ( DBCO ) group. 4-Arm-PEG10000-DBCO can be used for bioconjugation and drug delivery.
In Vitro, The structure of PEG-DBCO comprises two key parts that work synergistically: DBCO group: A highly reactive cyclic alkyne structure capable of undergoing copper-free click chemistry (azido-alkyne cycloaddition) with molecules containing an azide group (-N3). PEG chain: Acting as a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing nonspecific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.
In Vitro, The structure of PEG-DBCO comprises two key parts that work synergistically: DBCO group: A highly reactive cyclic alkyne structure capable of undergoing copper-free click chemistry (azido-alkyne cycloaddition) with molecules containing an azide group (-N3). PEG chain: Acting as a hydrophilic spacer, it forms a hydration layer on the particle surface, reducing nonspecific adsorption and immune system recognition and clearance, thus prolonging the carrier's circulation time in vivo.