Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5)

Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) is an antibody targeting CXCR3, which specifically binds to an epitope within amino acid residues 23 to 44 of human CXCR3 ^[1].

In Vivo, Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) (2-5 mg/kg; i.v.; single/weekly; 7-21 days) increases pancreatic islet allograft survival in mice, with a single 5 mg/kg dose boosting mean graft survival time from 17 to 33 days, and weekly 2 mg/kg doses achieving 35 days MST with long-term survival in some animals^[1]. Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) (0.5-10 mg/kg; i.v.; single dose) dose-dependently depletes CXCR3-expressing CD4+, CD8+, and B cells in mice, with complete depletion at doses ≥ 2 mg/kg lasting for more than 3 weeks^[1].

In Vitro, Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) specifically binds to mouse, human, and marmoset CXCR3 expressed on transfected cells and primary immune cells^[1]. Anti-Human/Mouse/Monkey CXCR3 Antibody (9C5) binds to an epitope within amino acid residues 23 to 44 of human CXCR3^[1].

References:
[1]. Charles Reay Mackay, et al. Anticorps et leurs utilisations. WO2014186842A1. 2014.