Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for researches on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer [1] [2] [3].
In Vivo, Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (250 μg, i.p., on day 0, 3, 6, 9 and 12) exhausts γδ T cells in the central nervous system (CNS) in TCRβ-/- mice infected with JHM virus[1]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., on day 0, 5 and 10) significantly reduces the incidence rate of arthritis in male B10.RIII mice with an IL-23 induced arthritis[2]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., twice weekly, for 4 weeks) can deplete γδ T cells in neu-transgenic mice bearing MMC tumors[3]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (500 µg, i.p., single dose, on day -3) significantly inhibits T cell infiltration in female BDF1 mice with a graft-versus-host disease (GVHD) model[4].
In Vitro, Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, 2 days) significantly reduces the number of γδ T cells in spleen and lymph nodes of mice[2]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (5 μg/mL, 48 h) enhances IFN-γ production in γδ T cells[3].
References:
[1]. Dandekar AA, et al. Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus. J Virol. 2005 Aug;79(15):9388-96.
[2]. Bouchareychas L, et al. γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. Sci Rep. 2018 May 15;8(1):7590.
[3]. Inatsuka C, et al. Gamma delta T cells are activated by polysaccharide K (PSK) and contribute to the anti-tumor effect of PSK. Cancer Immunol Immunother. 2013 Aug;62(8):1335-45.
[4]. Sakai T, et al. Host intestinal intraepithelial gamma delta T lymphocytes present during acute graft-versus-host disease in mice may contribute to the development of enteropathy. Eur J Immunol. 1995 Jan;25(1):87-91.
In Vivo, Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (250 μg, i.p., on day 0, 3, 6, 9 and 12) exhausts γδ T cells in the central nervous system (CNS) in TCRβ-/- mice infected with JHM virus[1]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., on day 0, 5 and 10) significantly reduces the incidence rate of arthritis in male B10.RIII mice with an IL-23 induced arthritis[2]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., twice weekly, for 4 weeks) can deplete γδ T cells in neu-transgenic mice bearing MMC tumors[3]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (500 µg, i.p., single dose, on day -3) significantly inhibits T cell infiltration in female BDF1 mice with a graft-versus-host disease (GVHD) model[4].
In Vitro, Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, 2 days) significantly reduces the number of γδ T cells in spleen and lymph nodes of mice[2]. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (5 μg/mL, 48 h) enhances IFN-γ production in γδ T cells[3].
References:
[1]. Dandekar AA, et al. Important roles for gamma interferon and NKG2D in gammadelta T-cell-induced demyelination in T-cell receptor beta-deficient mice infected with a coronavirus. J Virol. 2005 Aug;79(15):9388-96.
[2]. Bouchareychas L, et al. γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. Sci Rep. 2018 May 15;8(1):7590.
[3]. Inatsuka C, et al. Gamma delta T cells are activated by polysaccharide K (PSK) and contribute to the anti-tumor effect of PSK. Cancer Immunol Immunother. 2013 Aug;62(8):1335-45.
[4]. Sakai T, et al. Host intestinal intraepithelial gamma delta T lymphocytes present during acute graft-versus-host disease in mice may contribute to the development of enteropathy. Eur J Immunol. 1995 Jan;25(1):87-91.