Benocyclidine-d10

Benocyclidine-d₁₀ (BCP-d₁₀) contains ten deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, and 6' positions. It is intended for use as an internal standard for the quantification of BCP by GC- or LC-mass spectrometry. BCP is a derivative of phencyclidine with a benzothiophenyl group instead of a phenyl ring. It acts as a potent and selective dopamine reuptake inhibitor (IC₅₀ = 8 nM) with negligible affinity for the NMDA receptor-linked phencyclidine receptor (K_0.5 = 6 μM).^1,2 BCP has been used to label the dopamine transporter in the mouse brain.³ This product is intended for forensic and research applications.

1.Vignon, J., Pinet, V., Cerruti, C., et al.[3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP): A new phencyclidine analog selective for the dopamine uptake complexEuropean Journal of Pharmacology148(3)427-436(1988) 2.Chaudieu, I., Vignon, J., Chicheportiche, M., et al.Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogsPharmacology, Biochemistry, and Behavior32(3)699-705(1989) 3.Maurice, T., Vignon, J., Kamenka, J.M., et al.In vivo labelling of the mouse dopamine uptake complex with the phencyclidine derivative [3H]BTCPNeuroscience Letters101(2)234-238(1989)