CP 47,497 is a bicyclic cannabinoid analog with potent analgesic activity. [1] It is comparable or more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant and hypothermic effects in mice, rats, and dogs. [2] The levorotatory enantiomer, (-)-CP 47,497 avidly binds the CB1 receptor (Ki = 2.1 nM).[3]
Reference:
[1]. Melvin, L.S., Johnson, M.R., Harbert, C.A., et al. A cannabinoid derived prototypical analgesic. Journal of Medicinal Chemistry 27, 67-71 (1984).
[2]. Weissman, A., Milne, G.M., and Melvin, L.S., Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. Journal of Pharmacology and Experimental Therapeutics 223(2), 516-523 (1982).
[3]. Melvin, L.S., Milne, G.M., Johnson, M.R., et al. Structure-activity relationships defining the ACD-tricyclic cannabinoids: Cannabinoid receptor binding and analgesic activity. Drug Design and Discovery 13, 155-166 (1995).