DOTA-GA2 (tBu) 4 is a protected DOTA-based chelator precursor that can bind to radionuclides. DOTA-GA2 (tBu) 4 can be used to prepare radionuclide drugs, such as DOTADG-containing Exendin-4 derivatives [1] [2] [3].
References:
[1]. Iikuni S, et al. Development of an In-Labeled Glucagon-Like Peptide-1 Receptor-Targeting Exendin-4 Derivative that Exhibits Reduced Renal Uptake. Molecular pharmaceutics. 2022 Mar 07;19(3):1019-1027.
[2]. Hasegawa T, et al. Development of Novel Radiotheranostic Ligand with Positively Charged Unit Targeting Prostate-Specific Membrane Antigen. Journal of medicinal chemistry. 2025 May 22;68(10):10190-10202.
[3]. Nakashima K, et al. Systematic Investigation of Fatty Acids with Different Carbon-Chain Length as Albumin Binder to Improve Tumor Accumulation of Radioligands. Bioconjugate chemistry. 2026 Jul 15;37(7):1377-1385.
References:
[1]. Iikuni S, et al. Development of an In-Labeled Glucagon-Like Peptide-1 Receptor-Targeting Exendin-4 Derivative that Exhibits Reduced Renal Uptake. Molecular pharmaceutics. 2022 Mar 07;19(3):1019-1027.
[2]. Hasegawa T, et al. Development of Novel Radiotheranostic Ligand with Positively Charged Unit Targeting Prostate-Specific Membrane Antigen. Journal of medicinal chemistry. 2025 May 22;68(10):10190-10202.
[3]. Nakashima K, et al. Systematic Investigation of Fatty Acids with Different Carbon-Chain Length as Albumin Binder to Improve Tumor Accumulation of Radioligands. Bioconjugate chemistry. 2026 Jul 15;37(7):1377-1385.