Gabapentin-d4 |
Katalog-Nr.GC47388
One-Click Copy Product Info
|
An internal standard for the quantification of gabapentin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1185039-20-6
Sample solution is provided at 25 µL, 10mM.
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Gabapentin-d4 is intended for use as an internal standard for the quantification of gabapentin by GC- or LC-MS. Gabapentin is a γ-aminobutyric acid (GABA) analogue that acts as an anticonvulsant.1,2,3 It does not bind to GABA receptors, does not influence neural uptake of GABA, and does not inhibit the GABA-metabolizing enzyme, GABA transaminase.4,5 Unlike GABA, which does not pass through the blood-brain barrier, gabapentin penetrates into the central nervous system and binds to the α2δ-type voltage-gated calcium channels. Formulations containing gabapentin have been used to treat neuropathic pain caused by complex regional pain syndrome type one, cancer, and HIV as well as to control dysesthesias in patients with multiple sclerosis.1,2,3
1.van de Vusse, A.C., Stonmp-van de Berg, S.G.M., Kessels, A.H.F., et al.Randomised controlled trial of gabapentin in complex regional pain syndrome type I [ISRCTN84121379]BMC Neurol.4(13)(2004) 2.Hahn, K., Arendt, G., Braun, J.S., et al.A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathiesJ. Neurol.251(10)1260-1266(2004) 3.Caraceni, A., Zecca, E., Bonezzi, C., et al.Gabapentin for neuropathic cancer pain: A randomized controlled trial from the gabapentin cancer pain study groupJ. Clin. Oncol.22(14)2909-2917(2004) 4.Gee, N.S., Brown, J.P., Dissanayake, V.U.K., et al.The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channelJ. Biol. Chem.271(10)5768-5776(1996) 5.Goa, K.L., and Sorkin, E.M.Gabapentin. A review of its pharmacological properties and clinical potential in epilepsyDrugs46(3)409-427(1993)
| Cas No. | 1185039-20-6 | SDF | |
| Canonical SMILES | NC([2H])([2H])C1(C([2H])([2H])C(O)=O)CCCCC1 | ||
| Formula | C9H13D4NO2 | M.Wt | 175.3 |
| Löslichkeit | PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.7045 mL | 28.5225 mL | 57.0451 mL |
| 5 mM | 1.1409 mL | 5.7045 mL | 11.409 mL |
| 10 mM | 570.5 μL | 2.8523 mL | 5.7045 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)