Strychnine hydrochloride
Strychnine hydrochloride is a hydrochloride obtained by combining Strychnine with one molar equivalent of HCl. Strychnine has the effects of an aviicide, cholinergic antagonist, glycine receptor antagonist, rodenticide and neurotransmitter.
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| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 5mg | $93.00 | In Stock | 1 | |
| 10mg | $139.00 | In Stock | 1 | |
| 25mg | $263.00 | In Stock | 1 | |
| 50mg | $397.00 | In Stock | 1 | |
| 100mg | $618.00 | In Stock | 1 |
Zitate (Citations)
1 publicationsPublikationen von Forschern, die dieses Produkt verwendenBeschreibung (Description)
Strychnine hydrochloride is a hydrochloride obtained by combining Strychnine with one molar equivalent of HCl. Strychnine has the effects of an aviicide, cholinergic antagonist, glycine receptor antagonist, rodenticide and neurotransmitter[1, 2, 3]. Strychnine is a toxic alkaloid extract extracted from the dried mature seeds of Strychnos nux-vomica L.[4] Strychnine can selectively excite the spinal cord and enhance the tension of skeletal muscles. Strychnine hydrochloride is clinically used to treat mild paresis or amblyopia[5].
In vivo, Strychnine hydrochloride (0.1, 0.3, 0.9mg/kg) was orally treated with Wistar rats for 7 days. The high-dose group significantly reduced the activities of the three subfamilies of cytochrome P450 (CYP) CYP3A, CYP1A2, and CYP2C, and significantly increased the activity of CYP2E1[6].
References:
[1] Mohsen A M Y. Structure Activity Relationships of Monomeric and Dimeric Strychnine Analogs as Ligands Targeting Glycine Receptors [M]. Bayerische Julius-Maximilians-Universitaet Wuerzburg (Germany), 2016.
[2] Marrs T C, Maynard R L. Neurotransmission systems as targets for toxicants: A review [J]. Cell Biology and Toxicology, 2013, 29: 381-396.
[3] Patocka J. Strychnine [M]//Handbook of toxicology of chemical warfare agents. Academic Press, 2020: 239-247.
[4] Behera M C, Mohanty T L, Paramanik B K. Silvics, phytochemistry, and ethnopharmacy of endangered poison nut tree (Strychnos nux-vomica L.): A review [J]. Journal of Pharmacognosy and Phytochemistry, 2017, 6(5): 1207-1216.
[5] Huang N, Wang Y, Zhan G, et al. Contribution of skeletal muscular glycine to rapid antidepressant effects of ketamine in an inflammation-induced mouse model of depression [J]. Psychopharmacology, 2019, 236: 3513-3523.
[6] Gao Q, Wang J, Han F, et al. Effect of strychnine hydrochloride on liver cytochrome P450 mRNA expression and monooxygenase activities in rat [J]. Acta Pharmaceutica Sinica B, 2011, 1(2): 121-128.
Protokoll (Protocol)
| Animal experiment [1]: | |
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Animal models |
Male Wistar rats |
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Preparation Method |
A total of 18 rats were randomly divided into 6 groups (n=3/group) and given an oral dose of A: saline containing 0.5% CMC; B: Strychnine hydrochloride 0.1mg/kg/day; C: Strychnine hydrochloride 0.3mg/kg/day; D: Strychnine hydrochloride 0.9mg/kg/day; E: Strychnine hydrochloride 0.9mg/kg/day plus Glycyrrhetic acid 25mg/kg/day; and F: Strychnine hydrochloride 0.9mg/kg/day plus Liquiritin 20mg/kg/day once a day for 7 consecutive days. Animals were sacrificed 1h after the last dose and livers were immediately removed and sliced into two parts. One part was weighed, washed in cold homogenization buffer (0.25mol/L sucrose, 0.01mol/L tris–HCl, 1mmol/L EDTA, pH 7.4) and used to prepare rat liver microsomes (RLM)17. The other was stored in liquid nitrogen until used for mRNA extraction. |
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Dosage form |
0.1, 0.3, 0.9mg/kg/day for 7 days; p.o. |
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Applications |
Compared to control, the mRNA expressions of CYP3A1, 1A2 and 2E1 were higher in rats receiving the highest dose of Strychnine hydrochloride. CYP2E1 activity was higher and CYP2C, CYP3A and CYP1A2 activities were lower in rats receiving the highest dose of Strychnine hydrochloride. |
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References: |
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Produktdokumente (Product Documents)
Chemische Eigenschaften (Chemical Properties)
Verwenden Sie Stammlösungen bei Lagerung bei -80°C innerhalb von 6 Monaten bzw. bei -20°C innerhalb von 1 Monat.
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Rechner (Calculators)Molarität / Verdünnung / Molekulargewicht / Einheitenumrechnung / In-vivo-Formulierung / Löslichkeit
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