Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.
Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1].
Rimexolone (Org 6216) (0-450 渭g/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1].
[1]. Joosten LA, et al. Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonide. Agents Actions. 1990 Aug;31(1-2):135-42.
[2]. Foster CS, et al. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996 Aug;122(2):171-82.