Prostaglandins

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.

Prostaglandin K2 (PGK2) is the 9,11-diketone formed by the oxidation of PGE2 or PGD2.

15(S)-15-methyl Prostaglandin E1 (15(S)-15-methyl PGE1) is a metabolically stable synthetic analog of PGE1 .

Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.

16,16-dimethyl PGF2α is a metabolically stable analog of PGF2α.

16,16-dimethyl PGE1 is a metabolically stable synthetic analog of PGE1.

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.

16-phenoxy tetranor PGA2 is a minor metabolite found in human plasma after intravenous administration of sulprostone.

Found in human seminal plasma, 19(R)-hydroxy prostaglandin A2 (19(R)-hydroxy PGA2) is presumed to be a non-enzymatic dehydration metabolite of 19(R)-hydroxy PGE2, which is also found in semen.

3-methoxy PGF1α is a novel analog of PGF1α with a methoxy group in the 3-position of the upper side chain.

16,16-dimethyl PGF2β is a metabolically stable analog of PGF2β.

CAY10580 ist ein potenter und selektiver Prostaglandin-EP4-Rezeptoragonist (Ki=35 nM).

19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man.

6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes.

Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology.

Tolmetin β-D-glucuronide is a major phase II metabolite of tolmetin .

Prostaglandin A1 (PGA1) ethyl ester is a prodrug form of PGA1 with enhanced lipid solubility.

CAY10526 ist ein spezifischer Inhibitor der mikrosomalen PGE2-Synthase-1 (mPGES1). CAY10526 hemmt die PGE2-Produktion durch die selektive Modulation der mPGES1-Expression, wirkt sich jedoch nicht auf COX-2 aus. CAY10526 unterdr&Uuml;ckt signifikant das Tumorwachstum und erh&Ouml;ht die Apoptose in Melanom-Xenotransplantaten. CAY10526 reduziert die Proteinspiegel von BCL-2 und BCL-XL (anti-apoptotisch) und erh&Ouml;ht die Spiegel von BAX und BAK (pro-apoptotisch) sowie gespaltener Caspase 3. CAY10526 hemmt die Zelllebensf&Auml;higkeit (IC50<5 μM) in drei Melanom-Zelllinien, die mPGES1 exprimieren.

PGF1β is the C-9 epimer of PGF1α.

A stable analog of PGF 2α 2glyceryl ester

Prostaglandin D1(PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl.

AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC50s = 2.9 and >100 µM, respectively).

The actions of many clinical prostaglandins, including those used for estrous synchronization and for reduction of intraocular pressure, are mediated through the FP receptor.

Prostaglandin F2α alcohol (PGF2α-OH) is an analog of PGF2α in which the C-1 carboxyl group has been reduced to a primary alcohol.