Mazapertine is an orally active antipsychotic agent. M azapertine antagonizes to dopamine D2/3/4 receptors ( K i values < 3 nM) and also strongly binds to serotonin 5-HT1A receptor ( K i =1.7 nM) and α1-adrenergic receptor ( K i = 1.3 nM). Mazapertine can be used for the research of neurological disease [1].
References:
[1]. Reitz AB, et al. Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem. 1998 Jun 4;41(12):1997-2009.
References:
[1]. Reitz AB, et al. Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem. 1998 Jun 4;41(12):1997-2009.