N-Methylthalidomide is a cereblon ligand derivative that acts as an E3 ubiquitin ligase ligand for the synthesis of PROTAC LLC0424 N. LLC0424 N serves as a negative control for NSD2 PROTAC degrader LLC0424, with weak ability to induce NSD2 degradation and low growth inhibitory effect on cancer cells carrying NSD2 mutations [1].
References:
[1]. Liu L, et al. Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader[J]. Journal of Medicinal Chemistry, 2024, 67(9): 6938-6951.
References:
[1]. Liu L, et al. Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader[J]. Journal of Medicinal Chemistry, 2024, 67(9): 6938-6951.