RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer [1].
References:
[1]. TONG, et al. Macrocyclic compounds and therapeutic uses thereof. WO2024222864A1. WIPO (PCT). 2024-04-26.
References:
[1]. TONG, et al. Macrocyclic compounds and therapeutic uses thereof. WO2024222864A1. WIPO (PCT). 2024-04-26.