RES-701-3 peptide TFA is a class II lasso peptide. RES-701-3 peptide TFA can be isolated from the fermentation broth of Streptomyces species. RES-701-3 peptide TFA potently inhibits the binding of ET-1 to ET B, with an IC50 of approximately 5-10 nM. RES-701-3 peptide TFA is applicable to research related to systemic hypertension, myocardial infarction, and myocardial ischemia [1] [2].
In Vitro, RES-701-3 peptide TFA potently inhibits the binding of ET-1 to type B endothelin receptor, with an IC50 of approximately 5-10 nM[1].
References:
[1]. Oves-Costales D, et al. Identification, Cloning and Heterologous Expression of the Gene Cluster Directing RES-701-3, -4 Lasso Peptides Biosynthesis from a Marine Streptomyces Strain. Mar Drugs. 2020;18(5):238. Published 2020 May 1.
[2]. Ouyang X, et al. LassoPred: a tool to predict the 3D structure of lasso peptides. Nat Commun. 2025;16(1):5497. Published 2025 Jul 1.
In Vitro, RES-701-3 peptide TFA potently inhibits the binding of ET-1 to type B endothelin receptor, with an IC50 of approximately 5-10 nM[1].
References:
[1]. Oves-Costales D, et al. Identification, Cloning and Heterologous Expression of the Gene Cluster Directing RES-701-3, -4 Lasso Peptides Biosynthesis from a Marine Streptomyces Strain. Mar Drugs. 2020;18(5):238. Published 2020 May 1.
[2]. Ouyang X, et al. LassoPred: a tool to predict the 3D structure of lasso peptides. Nat Commun. 2025;16(1):5497. Published 2025 Jul 1.