Behavioral Neuroscience

Scopolamine (Hyoscine) is a natural tropane alkaloid and a high-affinity competitive muscarinic acetylcholine receptor (mAChRs) antagonist. Scopolamine reversibly inhibits 5-HT3 receptor responses with an IC 50 value of 2.09μM.

ICA-27243 ist ein selektiver, potenter und oral aktiver KCNQ2/Q3-KaliumkanalÖffner mit einem EC50 von 0,38 μM.

AZD7325 ist ein potentes und oral aktives partiell selektives PAM des GABAAα2- und Aα3-Rezeptors (Ki = 0,3 bzw. 1,3 nM) und hat eine geringere antagonistische Wirksamkeit bei den Aα1- und Aα5-Rezeptor-Subtypen.

SEP-363856-Hydrochlorid (SEP-856-Hydrochlorid), ein oral aktiver und ZNS-aktiver psychotroper Wirkstoff mit einem einzigartigen, nicht-D2/5-HT2A-Wirkungsmechanismus, Übt seine antipsychotisch Ähnlichen Wirkungen aus.

Donepezil N-oxide is an active metabolite of the acetylcholinesterase inhibitor donepezil.

Memantine-d6 is intended for use as an internal standard for the quantification of memantine by GC- or LC-MS.

Olanzapine-d8 is intended for use as an internal standard for the quantification of olanzapine by GC- or LC-MS.

Ramelteon-d5 is intended for use as an internal standard for the quantification of ramelteon by GC- or LC-MS.

Lurasidone metabolite 14283 is an active metabolite of the atypical antipsychotic lurasidone .

Risperidone is a benzisoxazole derivative used for treating schizophrenia, and also the psychotic, affective, or behavioral symptoms associated with other disorders.

Pirlindol ist ein selektiver und reversibler MAO-A-Hemmer.

Pioglitazone ketone is an active metabolite of the PPARγ agonist pioglitazone.

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate.

(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively).

(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist.

[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors.

13-Docosenamide is the amide of docosenoic acid.

An inactive metabolite of baclofen

4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine.

5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.

5-hydroxy-Nω-methyl Tryptamine is a metabolite of serotonin in humans that has also been found in plants.

6-hydroxy Chlorzoxazone is the primary metabolite of Chlorzoxazone in vivo. 6-hydroxy Chlorzoxazone is mainly formed through the hepatic cytochrome P450 enzyme system and is commonly used as a probe in biochemical research to quantitatively evaluate CYP2E1 activity.

6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.

ABD459 is a neutral antagonist of the central cannabinoid 1 (CB1) receptor (Ki = 8.6 nM).