[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) (Synonyms: Leu31,Pro34 NPY) |
| Katalog-Nr.GC41744 |
[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors.
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![[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) Chemische Struktur](/media/struct/GC4/GC41744.png "[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt) Chemische Struktur")
Sample solution is provided at 25 µL, 10mM.
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[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors. It reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s = 29.5 and 2.95 nM, respectively). It also binds to rhesus monkey Y2 and mouse Y6 receptors (Kis = 410 and 9.7 nM, respectively). In vitro, [Leu31,Pro34] NPY increases cellular protein mass by 25% in rat ventricular cardiomyocytes when used at a concentration of 10 nM. In vivo, [Leu31,Pro34] NPY (0.7-7 nmol, i.c.v.) increases food intake in rats.
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