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Aryl Hydrocarbon Receptor

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Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.

Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

Products Related to Aryl Hydrocarbon Receptor(40)

  • GC64208 structure
    GC64208AHR antagonist 5 free base
    CAS: 2247950-42-9
    Purity: >98%

    Die freie Base des AHR-Antagonisten 5 ist ein selektiver und oral aktiver Arylhydrocarbonrezeptor (AHR)-Inhibitor. Die freie Base des AHR-Antagonisten 5 blockiert wirksam die Translokation von AHR aus dem Zytoplasma in den Zellkern. Die freie Base des AHR-Antagonisten 5 ist hochgradig selektiv fÜr AHR gegenÜber anderen Rezeptoren, Transportern und Kinasen.

  • GC64275 structure
    GC64275AHR antagonist 5
    CAS: 2247953-39-3
    Purity: >98%

    AHR-Antagonist 5, ein potenter und oral aktiver Arylhydrocarbonrezeptor (AHR)-Antagonist, extrahiert aus Patent WO2018195397, Beispiel 39, hat einen IC50 von < 0,5 μμ. AHR-Antagonist 5 hemmt signifikant das Tumorwachstum in Kombination mit dem Checkpoint-Inhibitor Anti-PD-1.

  • GC64898 structure
    GC64898L-Kynurenine-d4-1
    CAS: 194546-33-3
    Purity: >98%
  • GC67892 structure
    GC67892CHD-5
    CAS: 289494-16-2
    Purity: >98%
  • GC68631 structure
    GC68631AhR agonist 2
    Purity: >99.50%

    AhR-Agonist 2 (Verbindung 12a) is an effective aryl hydrocarbon receptor (AhR) agonist with an EC50 of 0.03 nM. AhR-Agonist 2 induces rapid nuclear enrichment of AhR, triggers transcription of downstream genes and promotes skin barrier repair. AhR-Agonist 2 has the potential to be studied for psoriasis treatment.

  • GC69347 structure
    GC69347KYN-101
    CAS: 2247950-73-6
    Purity: >98.00%

    KYN-101 ist ein wirksamer, selektiver und oral aktiver AHR-Inhibitor. KYN-101 reduziert die mRNA-Expression von CYP1A1. KYN-101 hat antitumorale Aktivität.

  • GC69908 structure
    GC69908Skatole-d3
    CAS: 111399-60-1
    Purity: >98.00%

    Skatole-d3 ist das Deuterium-Isotop von Skatole. Skatole ist eine Substanz, die von Darmbakterien produziert wird und durch Aktivierung von Arylhydrocarbonrezeptoren und p38 die Funktion der Darmepithelzellen reguliert.

  • GC70236 structure
    GC70236L-Kynurenine-13C10 sulfate hemihydrate
    Purity: >99.00%

    L-Kynurenine-13C10 sulfate hemihydrate ist das 13C markierte L-Kynureninsulfat.

  • GC72826 structure
    GC72826CB7993113
    CAS: 819827-50-4
    Purity: >98.00%

    CB7993113 ist ein starker AHR-Antagonist mit einem IC50 von 0,33 μM.

  • GC72948 structure
    GC72948Dibenzo(a,i)pyrene
    CAS: 189-55-9
    Purity: >98.00%

    Dibenzo(a,i)pyrene ist ein 2,3,7,8-Tetrachlordibenzo-p-dioxin TCDD-Rezeptor-Ligand.

  • GC74164 structure
    GC7416425-Hydroxytachysterol3
    CAS: 39932-44-0
    Purity: >98.00%

    25-Hydroxytachysterol3 ist der Metabolit von Vitamin D3.

  • GC79337 structure
    GC79337ZSTK3744
    Purity: >98.00%

    ZSTK3744 is an aryl hydrocarbon receptor ( AhR ) agonist.

  • GC79341 structure
    GC79341N-Methylscatole
    CAS: 875-30-9
    Purity: >98.00%

    N-Methylscatole (compound 70130) is a weak aryl hydrocarbon receptor ( AhR ) agonist exhibiting no significant antagonistic activity [1] .

  • GC79342 structure
    GC793429,10-Dichlorophenanthrene
    CAS: 17219-94-2
    Purity: >98%

    9,10-Dichlorophenanthrene is a chlorinated polycyclic aromatic hydrocarbon and is generally regarded as a carcinogen.

  • GC79393 structure
    GC79393PY109
    CAS: 2378039-23-5
    Purity: >99.00%

    PY109 is an orally active and highly selective aryl hydrocarbon receptor ( AHR ) agonist.

  • GN10706 structure
    GN10706Diosimin
    CAS: 520-27-4
    Purity: >98.00%