GLPBio

Reactive Oxygen Species

Read More about this category

Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products Related to Reactive Oxygen Species(505)

  • GC44672 structure
    GC44672PPHP
    CAS: 87864-20-8
    Purity: >98.00%

    PPHP is a substrate for the measurement of peroxidase enzymes.

  • GC44860 structure
    GC44860S1QEL1.1
    CAS: 897613-29-5
    Purity: >98.00%

    S1QEL1.1 is a small molecule that suppresses superoxide production during reverse electron transport through the IQ site of the mitochondrial respiratory complex I (IC50 = 70 nM) without affecting oxidative phosphorylation.

  • GC44918 structure
    GC44918SOTS-1 (technical grade)
    CAS: 223507-96-8
    Purity: >80.00%

    Superoxide radical anion is a toxic by-product of mitochondrial respiration that is formed from approximately 1-4% of the oxygen metabolized by aerobic organisms.

  • GC44947 structure
    GC44947SRS16-86
    CAS: 1793052-96-6
    Purity: >98.00%

    SRS16-86 ist ein potenter Inhibitor der Ferroptose.

  • GC44989 structure
    GC44989TAN 420E
    CAS: 91700-93-5
    Purity: >95.00%

    TAN 420E is a bacterial metabolite originally isolated from Streptomyces.

  • GC45010 structure
    GC45010TEMPONE
    CAS: 2896-70-0
    Purity: >98.00%

    2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO) is a stable radical that will react with reactive oxygen species (ROS).

  • GC45059 structure
    GC45059TMB (hydrochloride hydrate)
    CAS: 207738-08-7
    Purity: >98.00%

    TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate.

  • GC45066 structure
    GC45066Tosyl Phenylalanyl Chloromethyl Ketone
    CAS: 402-71-1
    Purity: >97.00%

    Tosyl-Phenylalanyl-Chloromethyl-Keton (L-1-Tosylamido-2-Phenylethyl-Chloromethyl-Keton; L-Tosyl-Phenylalanyl-Chloromethyl-Keton) ist ein potenter Serinprotease-Inhibitor, der mit dem Retinoblastoma-Protein (RB)-bindenden Kern des HPV-18-E7-Proteins reagiert und abschafft seine RB-BindungsfÄhigkeit.

  • GC45131 structure
    GC45131Urotensin II (human) (trifluoroacetate salt)
    Purity: >95.00%

    Urotensin II is a somatostatin-like neuropeptide agonist of the urotensin II receptor (UTR; Ki = 2 nM).

  • GC45226 structure
    GC45226β-BHC
    CAS: 319-85-7
    Purity: 95.00%

    β-BHC is an isomer of the organochlorine pesticide γ-lindane that is a potential impurity found in commercial preparations of lindane.

  • GC45248 structure
    GC45248(-)-FINO2
    CAS: 869298-31-7
    Purity: >98.00%

    (-)-FINO2 ist ein potenter Ferroptose-Induktor. (-)-FINO2 hemmt die AktivitÄt von GPX4. (-)-FINO2 ist ein stabiles Oxidationsmittel, das Eisen oxidiert und bei unterschiedlichen pH-Werten stabil ist. (-)-FINO2 verursacht eine weit verbreitete Lipidperoxidation.

  • GC45337 structure
    GC453373-Hydroxyterphenyllin
    CAS: 66163-76-6
    Purity: >70.00%

    3-Hydroxyterphenyllin ist ein Metabolit von Aspergillus candidus. 3-Hydroxyterphenyllin unterdrÜckt die Proliferation und verursacht ZytotoxizitÄt gegenÜber A2780/CP70- und OVCAR-3-Zellen. 3-Hydroxyterphenyllin induziert S-Phasen-Arrest und Apoptose. 3-Hydroxyterphenyllin hat das Potenzial fÜr die Erforschung von Eierstockkrebs.

  • GC45357 structure
    GC453575-Chlorouracil
    CAS: 1820-81-1
    Purity: >98.00%

  • GC45379 structure
    GC45379Alloxan (hydrate)
    CAS: 2244-11-3
    Purity: >98.00%

  • GC45427 structure
    GC45427Dihydrolycorine
    CAS: 6271-21-2
    Purity: >98.00%

  • GC45513 structure
    GC45513MGR1
    CAS: 2361529-46-4
    Purity: >98.00%

  • GC45578 structure
    GC45578Thymohydroquinone
    CAS: 2217-60-9
    Purity: >98.00%

  • GC45595 structure
    GC45595Vulpinic Acid
    CAS: 521-52-8
    Purity: >98.00%

    VulpinsÄure, ein Flechtenmetabolit, verringert die H2O2-induzierte ROS-Produktion, oxidativen Stress und oxidativen Stress-bedingte SchÄden in humanen Nabelvenen-Endothelzellen (HUVEC).

  • GC45662 structure
    GC45662Dieugenol
    CAS: 4433-08-3
    Purity: >98.00%

    A neolignan with antioxidative and antiparasitic activities

  • GC45706 structure
    GC45706GHK-Cu (acetate)
    CAS: 300801-03-0
    Purity: >98.00%

    A tripeptide-copper(II) complex

  • GC45777 structure
    GC45777Peonidin 3-O-glucoside (chloride)
    CAS: 6906-39-4
    Purity: >97.00%

    Peonidin 3-O-Glucosid (Chlorid), ein Anthocyanin, wirkt als Insulin-Sekretagogum.

  • GC45820 structure
    GC45820Balsalazide-d4
    Purity: >99.00%

    Balsalazid-d4 ist Deuterium mit der Bezeichnung Balsalazid.

  • GC45877 structure
    GC45877CYM 5478
    CAS: 870762-83-7
    Purity: >98.00%

    CYM 5478 ist ein potenter und hochselektiver S1P2-Agonist mit einem EC50-Wert von 119 nM in einem TGFα-Shedding-Assay.

  • GC45917 structure
    GC45917Leucettine L41
    CAS: 1112978-84-3
    Purity: >98.00%

    Leucettin L41 ist ein potenter Inhibitor der dualspezifischen Tyrosin-Phosphorylierungs-regulierten Kinase 1A (DYRK1A), DYRK2, CDC-Ähnlicher Kinase 1 (CLK1) und CLK3 (IC50s = 0,04, 0,035, 0,015 bzw. 4,5 μM)[1 ].