E3 Ligase Ligand-Linker Conjugate
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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
Products Related to E3 Ligase Ligand-Linker Conjugate(201)
- GC80908E3 ligase Ligand 63-N-CH2-Ph-O-CH3CAS: 2357109-91-0Purity: >98.00%
E3 ligase Ligand 63-N-CH2-Ph-O-CH3 is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
- GC80909Thalidomide-NH-C5-NH2 TFACAS: 2093386-40-2Purity: >97.00%
Thalidomide-NH-C5-NH2 (TFA) is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
- GC80910(3S)Lenalidomide-5-methylpiperazine benzenesulfonateCAS: 2229714-16-1Purity: >95.00%
(3S)Lenalidomide-5-methylpiperazine benzenesulfonate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.
- GC80911Acepromazine-1-piperazinepropanamine dihydrochloridePurity: >99.00%
Acepromazine-1-piperazinepropanamine dihydrochloride (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a TRIM21 ligand and a linker.
- GC80912(S,R,S)-AHPC-Me-CO-C4-COOHCAS: 2349429-73-6Purity: >99.50%
(S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12.
- GC80913(S,R,S)-AHPC-Me-CO-C6-COOHCAS: 2365173-02-8Purity: >95.00%
(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC.
- GC80914(S,R,S)-AHPC-C5-NH2 hydrochlorideCAS: 2170695-20-0Purity: >95.00%
(S,R,S)-AHPC-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC.
- GC80915(S,R,S)-AHPC-Me-amide-C-O-PEG2-COOHCAS: 2250056-22-3Purity: >98.00%
(S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH is an E3 ligase ligand-linker conjugate.
- GC81832E3 ligase Ligand 64-2-(4-hydroxypiperidin-4-yl)acetic acidCAS: 2654826-81-8Purity: >98.00%
E3 ligase Ligand 64-2-(4-hydroxypiperidin-4-yl) acetic acid is an E3 ligase-linker conjugate.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC80908 | E3 ligase Ligand 63-N-CH2-Ph-O-CH3 | 2357109-91-0 | >98.00% | |
E3 ligase Ligand 63-N-CH2-Ph-O-CH3 is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC. | ||||
| GC80909 | Thalidomide-NH-C5-NH2 TFA | 2093386-40-2 | >97.00% | |
Thalidomide-NH-C5-NH2 (TFA) is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC. | ||||
| GC80910 | (3S)Lenalidomide-5-methylpiperazine benzenesulfonate | 2229714-16-1 | >95.00% | |
(3S)Lenalidomide-5-methylpiperazine benzenesulfonate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC. | ||||
| GC80911 | Acepromazine-1-piperazinepropanamine dihydrochloride | - | >99.00% | |
Acepromazine-1-piperazinepropanamine dihydrochloride (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a TRIM21 ligand and a linker. | ||||
| GC80912 | (S,R,S)-AHPC-Me-CO-C4-COOH | 2349429-73-6 | >99.50% | |
(S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12. | ||||
| GC80913 | (S,R,S)-AHPC-Me-CO-C6-COOH | 2365173-02-8 | >95.00% | |
(S,R,S)-AHPC-Me-CO-C6-COOH is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. | ||||
| GC80914 | (S,R,S)-AHPC-C5-NH2 hydrochloride | 2170695-20-0 | >95.00% | |
(S,R,S)-AHPC-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate containing a VHL ligand and linker based on (S,R,S)-AHPC. | ||||
| GC80915 | (S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH | 2250056-22-3 | >98.00% | |
(S,R,S)-AHPC-Me-amide-C-O-PEG2-COOH is an E3 ligase ligand-linker conjugate. | ||||
| GC81832 | E3 ligase Ligand 64-2-(4-hydroxypiperidin-4-yl)acetic acid | 2654826-81-8 | >98.00% | |
E3 ligase Ligand 64-2-(4-hydroxypiperidin-4-yl) acetic acid is an E3 ligase-linker conjugate. | ||||