Lipoxygenase
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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.
Products Related to Lipoxygenase(264)
- GC4192615(S)-HETE-biotinCAS: 1217461-45-4Purity: >95.00%
15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway.
- GC4192715(S)-HETrECAS: 92693-02-2Purity: >98.00%
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid.
- GC4193815-Lipoxygenase Inhibitor 1CAS: 928853-86-5Purity: >99.50%
15-Lipoxygenase-Inhibitor 1 ist ein selektiver Inhibitor der 15-Lipoxygenase mit einem IC50-Wert von 18 μM. 15-Lipoxygenase-Inhibitor 1 hat IC50s von 19,5 μM und 19,1 ⋼M fÜr Sojabohnen-15-Lipoxygenase (SLO) bzw. menschliche 15-Lipoxygenase-1 (15-LOX-1). 15-Lipoxygenase Inhibitor 1 hat Potenzial fÜr die Erforschung von Prostatakrebs.
- GC4195117(R)-Resolvin D1CAS: 528583-91-7Purity: >95.00%
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.
- GC4195217(R)-Resolvin D4CAS: 528583-89-3Purity: >98.00%
17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 .
- GC4198018-carboxy dinor Leukotriene B4CAS: 102674-12-4Purity: >97.00%
18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4.
- GC420391-Stearoyl-2-15(S)-HETE-sn-glycero-3-PCCAS: 154436-51-8Purity: >98.00%
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.
- GC420401-Stearoyl-2-15(S)-HETE-sn-glycero-3-PECAS: 947381-58-0Purity: >98.00%
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position.
- GC420411-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PCCAS: 154436-48-3Purity: >98.00%
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.
- GC420421-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PECAS: 154436-49-4Purity: >90.00%
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position.
- GC4208220-carboxy Leukotriene B4CAS: 80434-82-8Purity: >97.00%
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils.
- GC424795(S)-HETrECAS: 195061-94-0Purity: >98.00%
5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate.
- GC426198(S)-HETrECAS: 889573-69-7Purity: >98.00%
8(S)-HETrE is a monohydroxy polyunsaturated fatty acid produced by rabbit neutrophil lipoxygenase when dihomo-γ-linolenic acid is used as a substrate.
- GC426369(S)-HOTrECAS: 89886-42-0Purity: >98.00%
9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid.
- GC426379(S)-HpOTrECAS: 111004-08-1Purity: >98.00%
9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid.
- GC426519-oxo-10(E),12(E)-Octadecadienoic AcidCAS: 54232-58-5Purity: >90.00%
9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxoODA) is a natural agonist, abundant in tomatoes, that activates PPARα at 10-20 μM.
- GC43453DiflapolinCAS: 724453-98-9Purity: >99.00%
Diflapolin ist ein hochaktiver dualer 5-Lipoxygenase-aktivierendes Protein (FLAP)/lÖsliche Epoxidhydrolase (sEH)-Inhibitor mit ausgeprÄgter entzÜndungshemmender Wirksamkeit und hoher ZielselektivitÄt.
- GC43459Dihydro MontelukastCAS: 142147-67-9Purity: >98.00%
Dihydro montelukast is a potential impurity found in commercial montelukast preparations.
- GC43616EOS (d18:1/32:1/18:2)CAS: 1318771-31-1Purity: >95.00%
EOS is a ceramide found in the outer layer of the epidermis in mammals.
- GC44052Leukotriene B4 dimethyl amideCAS: 83024-92-4Purity: >97.00%
LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC41926 | 15(S)-HETE-biotin | 1217461-45-4 | >95.00% | |
15(S)-HETE is a major arachidonic acid metabolite produced by the 15-lipoxygenase pathway. | ||||
| GC41927 | 15(S)-HETrE | 92693-02-2 | >98.00% | |
15(S)-HETrE is the hydroxy-trienoic acid resulting from 15-lipoxygenation of dihomo-γ-linolenic acid. | ||||
| GC41938 | 15-Lipoxygenase Inhibitor 1 | 928853-86-5 | >99.50% | |
15-Lipoxygenase-Inhibitor 1 ist ein selektiver Inhibitor der 15-Lipoxygenase mit einem IC50-Wert von 18 μM. 15-Lipoxygenase-Inhibitor 1 hat IC50s von 19,5 μM und 19,1 ⋼M fÜr Sojabohnen-15-Lipoxygenase (SLO) bzw. menschliche 15-Lipoxygenase-1 (15-LOX-1). 15-Lipoxygenase Inhibitor 1 hat Potenzial fÜr die Erforschung von Prostatakrebs. | ||||
| GC41940 | 15-OxoEDE | 105835-44-7 | >95.00% | |
15-OxoEDE is produced by the oxidation of 15-HEDE. | ||||
| GC41951 | 17(R)-Resolvin D1 | 528583-91-7 | >95.00% | |
Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid. | ||||
| GC41952 | 17(R)-Resolvin D4 | 528583-89-3 | >98.00% | |
17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 . | ||||
| GC41980 | 18-carboxy dinor Leukotriene B4 | 102674-12-4 | >97.00% | |
18-carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. | ||||
| GC42039 | 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC | 154436-51-8 | >98.00% | |
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. | ||||
| GC42040 | 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE | 947381-58-0 | >98.00% | |
1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HETE at the sn-2 position. | ||||
| GC42041 | 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC | 154436-48-3 | >98.00% | |
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. | ||||
| GC42042 | 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE | 154436-49-4 | >90.00% | |
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid at the sn-1 position and 15(S)-HpETE at the sn-2 position. | ||||
| GC42082 | 20-carboxy Leukotriene B4 | 80434-82-8 | >97.00% | |
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. | ||||
| GC42479 | 5(S)-HETrE | 195061-94-0 | >98.00% | |
5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate. | ||||
| GC42619 | 8(S)-HETrE | 889573-69-7 | >98.00% | |
8(S)-HETrE is a monohydroxy polyunsaturated fatty acid produced by rabbit neutrophil lipoxygenase when dihomo-γ-linolenic acid is used as a substrate. | ||||
| GC42636 | 9(S)-HOTrE | 89886-42-0 | >98.00% | |
9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid. | ||||
| GC42637 | 9(S)-HpOTrE | 111004-08-1 | >98.00% | |
9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. | ||||
| GC42651 | 9-oxo-10(E),12(E)-Octadecadienoic Acid | 54232-58-5 | >90.00% | |
9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxoODA) is a natural agonist, abundant in tomatoes, that activates PPARα at 10-20 μM. | ||||
| GC42653 | 9-OxoOTrE | 125559-74-2 | >95.00% | |
9-OxoOTrE is produced by the oxidation of 9-HpOTrE. | ||||
| GC43153 | CAY10416 | 443919-96-8 | >95.00% | |
Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. | ||||
| GC43194 | CAY10698 | 684236-01-9 | >98.00% | |
CAY10698 (Verbindung 1) ist ein potenter und selektiver Inhibitor von 12-Lipoxygenase (12-LOX) mit einem IC50 von 5,1 μM. | ||||
| GC43453 | Diflapolin | 724453-98-9 | >99.00% | |
Diflapolin ist ein hochaktiver dualer 5-Lipoxygenase-aktivierendes Protein (FLAP)/lÖsliche Epoxidhydrolase (sEH)-Inhibitor mit ausgeprÄgter entzÜndungshemmender Wirksamkeit und hoher ZielselektivitÄt. | ||||
| GC43459 | Dihydro Montelukast | 142147-67-9 | >98.00% | |
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. | ||||
| GC43616 | EOS (d18:1/32:1/18:2) | 1318771-31-1 | >95.00% | |
EOS is a ceramide found in the outer layer of the epidermis in mammals. | ||||
| GC44052 | Leukotriene B4 dimethyl amide | 83024-92-4 | >97.00% | |
LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. | ||||