GLPBio

DYRK

Read More about this category

Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

Products Related to DYRK(38)

  • GC70625 structure
    GC70625AnnH31
    CAS: 241809-12-1
    Purity: >99.00%

    AnnH31 ist ein Dyrk1A-Hemmer (IC50: 81 nM).

  • GC70985 structure
    GC70985Dyrk1A-IN-3
    CAS: 2493976-27-3
    Purity: >99.00%

    Dyrk1A-IN-3 (Compound 8b), ein hochselektiver, dual-spezifischer Tyrosin-regulierter Kinase 1A (DYRK1A)-Inhibitor, hält eine hohe DYRK1A-Bindungsaffinität (IC50=76 nM) aufrecht.

  • GC71197 structure
    GC71197FINDY
    CAS: 1507367-37-4

    FINDY ist ein faltender intermediär-selektiver Inhibitor von DYRK1A.

  • GC72931 structure
    GC72931HTH-01-091 TFA
    Purity: >98.00%

    HTH-01-091 TFA ist ein potenter und selektiver mütterlicher embryonaler Leucin Zipper Kinase (MELK)-Hemmer mit einem IC50 von 10,5 nM.

  • GC72982 structure
    GC72982BT173
    CAS: 2232180-74-2
    Purity: >98.00%

    BT173 ist ein starker Homöodomain interagierender Proteinkinase 2 (HIPK2)-Hemmer.

  • GC73224 structure
    GC73224CLK1-IN-3
    CAS: 2922550-28-3
    Purity: >98.00%

    CLK1-IN-3 (Verbindung 10ad) ist ein potenter und selektiver Clk1-Inhibitor mit einem IC50 von 5 nM und über 300-facher Selektivität für Dyrk1A.

  • GC73707 structure
    GC73707ON 108600
    CAS: 1585246-23-6
    Purity: >99.00%

    ON 108600 ist ein Hemmer für CK2 (Casein Kinase2)/TNIK/DYRK1 ,mit den IC50 für DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2 und TNIK von 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM bzw. 0.005 μM.

  • GC74165 structure
    GC741654-(Trifluoromethyl)aniline-d4
    CAS: 1219795-48-8
    Purity: >99.00%

    4-(Trifluoromethyl)aniline-d4 ist Deuterium markiert 4-Trifluormetlanilin.

  • GC74261 structure
    GC74261(R)-(+)-O-Demethylbuchenavianine
    CAS: 1364123-68-1
    Purity: >98.00%

    (R)-(+)-O-Demethylbuchenavianine ist ein Hemmer für cyclinabhängige Kinasen CDK.

  • GC80874 structure
    GC80874ARN25699
    Purity: >98%

    ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.

  • GC81300 structure
    GC81300PROTAC DYRK2 degrader-2
    CAS: 3061366-74-0
    Purity: >98.00%

    PROTAC DYRK2 degrader-2 is a PROTAC DYRK2 degrader based on curcumin analog A3.

  • GC81307 structure
    GC81307DYRK2-IN-2
    CAS: 2416195-65-6
    Purity: >98%

    DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC 50 value being 40.3 nM.

  • GC81308 structure
    GC81308DYRK2-IN-2 hydrochloride
    Purity: >98.00%

    DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC 50 of 40.3 nM.

  • GC81309 structure
    GC81309AO-365/43472821
    CAS: 1081122-55-5
    Purity: >99.50%

    AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A ( DYRK1A ) inhibitor ( IC 50 = 0.29 μM) and shows a significant inhibitory effect on ( CDC-like kinase 1) CLK1 ( IC 50 = 0.08 μM).