SIRT3 activator 1 (Compound 5v) is a SIRT3 activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases[1].
In Vitro, SIRT3 activator 1 (0-10 μM) protects cardiomyocytes against oxidative damage induced by Doxorubicin (HY-15142A) in H9c2 cells by activating the SIRT3/SOD2 and OPA1 pathways[1].
References:
[1]. Chen Z, et al. Design, Synthesis, and In Vivo Evaluation of Isosteviol Derivatives as New SIRT3 Activators with Highly Potent Cardioprotective Effects. J Med Chem. 2024 Apr 25;67(8):6749-6768.