SR-4554 is a probe for the measurement of tumor hypoxia. SR-4554 undergoes enzymatic single-electron reduction reactions within hypoxic cells. SR-4554 determines the 19 F retention index for four commonly used mouse tumors (EMT6, SCCVII, KILT and RIF-I) through 19 F MRS technique. SR-4554 can used to detect tumor Hypoxia noninvasively by 19 F magnetic resonance spectroscopy ( 19 F MRS) [1].
References:
[1]. Aboagye EO, et al. Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia. Cancer Res. 1997 Aug 1;57(15):3314-8.
References:
[1]. Aboagye EO, et al. Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia. Cancer Res. 1997 Aug 1;57(15):3314-8.