Zandelisib (Synonyms: ME-401; PWT-143) |
Katalog-Nr.GC62480 |
Zandelisib (ME-401) ist ein Inhibitor der Phosphatidylinositol-3-Kinase (PI3K), extrahiert aus dem Patent WO2019183226 A1, Verbindungsbeispiel 1. Zandelisib hemmt selektiv p110δ mit einem IC50 von 3,5 nM. Zandelisib wirkt als antineoplastisches Mittel.
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Cas No.: 1401436-95-0
Sample solution is provided at 25 µL, 10mM.
Zandelisib (ME-401) is a phosphatidylinositol 3-kinase (PI3K) inhibitor extracted from patent WO2019183226 A1, Compound Example 1. Zandelisib selectively inhibits p110δ with an IC50 of 3.5 nM. Zandelisib functions as an antineoplastic[1][2].
Zandelisib inhibits PI3Ks with IC50s of 4, 976 nM, 605 nM, 817 nM and 3.5 nM for p110α, p110β, p110γ and p110δ, respectivey[1].
[1]. Daniel P. Gold, et al. Combination therapy. WO2019183226A1.
[2]. David Brown, et al. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases. WO2014055647A1.
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