Zinc protoporphyrin IX (Synonyms: ZnPPIX) |
Katalog-Nr.GC11208 |
Zinkprotoporphyrin IX (Zn(II)-protoporphyrin IX) ist ein oral aktiver und kompetitiver Häm-Sauerstoffase-1 (HO-1)-Inhibitor und schwächt die schützenden Wirkungen von Phloroglucinol (PG) gegen H2O2 deutlich ab.
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Cas No.: 15442-64-5
Sample solution is provided at 25 µL, 10mM.
Zinc protoporphyrin IX (ZnPP) is a member of metalloporphyrins in which the heme iron is replaced by zinc, which becomes a competitive inhibitor of heme oxygenase 1 (HO-1) [1].
Zinc protoporphyrin IX tested presented anti-vesicular stomatitis virus (VSV) activity without photoactivation, with the reduction in viral titer being about 10-fold for 1 µM Zinc protoporphyrin. At 5 µM, Zinc protoporphyrin IX tested were able to completely abolish VSV infectivity. Photoactivation of the porphyrins significantly enhanced their antiviral activities, with 0.1 µM ZnPPIX completely abolishing VSV infectivity [2]. Zinc protoporphyrin IX (ZnPP) (5 µM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h in C-26 cells[3]. Zinc protoporphyrin IX (1.25-40 µM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against human ovarian carcinoma (MDAH2774), human pancreatic adenocarcinoma (Mia PaCa2), human breast carcinoma (MDA-MB231), murine breast carcinoma (EMT6) cell lines [3].
Zinc Protoporphyrin IX (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o. for 7days) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth in BALB/c mice inoculated with C-26 cells [3]. Zinc Protoporphyrin IX (5 and 20 µg/mouse) dose-dependently inhibited tumor growth in LL/2-tumor model mice. Vascular endothealial growth factor concentration in tumors was reduced by Zinc Protoporphyrin IX [4].
References:
[1]. Fang J, Greish K, Qin H, et al. HSP32 (HO-1) inhibitor, copoly (styrene-maleic acid)-zinc protoporphyrin IX, a water-soluble micelle as anticancer agent: In vitro and in vivo anticancer effect[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2012, 81(3): 540-547.
[2]. Cruz-Oliveira C, Almeida A F, Freire J M, et al. Mechanisms of vesicular stomatitis virus inactivation by protoporphyrin IX, zinc-protoporphyrin IX, and mesoporphyrin IX[J]. Antimicrobial agents and chemotherapy, 2017, 61(6): e00053-17.
[3]. Nowis D, Bugajski M, Winiarska M, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice[J]. BMC cancer, 2008, 8(1): 1-12.
[4]. Hirai K, Sasahira T, Ohmori H, et al. Inhibition of heme oxygenase‐1 by zinc protoporphyrin IX reduces tumor growth of LL/2 lung cancer in C57BL mice[J]. International Journal of Cancer, 2007, 120(3): 500-505.
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