GLPBio

DFHO

Catalog No.: GC50451Purity:>99.50%
RFP fluorophore mimic for imaging RNA in living cells; activated by binding Corn aptamers

Products are for research use only. Not for human use. We do not sell to patients.


DFHO
Cas No.: 1420815-34-4
1mgIn Stock
$109.00
1
5mgIn Stock
$236.00
1
10mgIn Stock
$378.00
1

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

Mimic of red fluorescent protein (RFP) fluorophore for imaging RNA in living cells. Fluorescence is activated by binding to Corn aptamer (Kd = 70 nM). Excitation/emission maxima (λ) = 505/545 nm; extinction coefficient = 29000 M-1 cm-1.

Song et al (2017) Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex. Nat.Chem.Biol. 13 1187 PMID:28945233 |Warner et al (2017) A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat.Chem.Biol. 13 1195 PMID:28945234

Product Documents

Purity:>99.50%Appearance:A solid

Chemical Properties

CAS No.
1420815-34-4
SMILES
CN1C(/C=N/O)=N/C(C1=O)=C\C2=CC(F)=C(C(F)=C2)O
Molecular Formula
C12H9F2N3O3
Molecular Weight
281.22
Solubility
DMSO : 100 mg/mL (355.61 mM; Need ultrasonic)
Storage
4°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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