DMBP is a VPS41 inhibitor. DMBP induces methuosis and inhibits autophagy in cancer cells. DMBP inhibits the fusion of late endosomes and autophagosomes with lysosomes. DMBP effectively inhibits metastasis in a mouse metastatic melanoma model. DMBP can be used for the study of melanoma [1].
References:
[1]. Liu Y, et al. Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells. Cell Chem Biol. 2023 Feb 16;30(2):130-143.e5.
References:
[1]. Liu Y, et al. Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells. Cell Chem Biol. 2023 Feb 16;30(2):130-143.e5.