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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. Product Name Information
  2. GC30761 α-Hydroxylinoleic acid α-Hydroxylinoleic acid (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. α-Hydroxylinoleic acid Chemical Structure
  3. GC46008 (±)-Thalidomide-d4 An internal standard for the quantification of (±)-thalidomide (±)-Thalidomide-d4 Chemical Structure
  4. GC34960 (+)-Talarozole (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. (+)-Talarozole Chemical Structure
  5. GC10603 (-)-epicatechin gallate major catechin in green tea (-)-epicatechin gallate Chemical Structure
  6. GC17242 (-)-epigallocatechin green tea epicatechin (-)-epigallocatechin Chemical Structure
  7. GC14049 (-)-Epigallocatechin gallate (EGCG) (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) .. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  8. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively. (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) Chemical Structure
  9. GC60395 (3S,5R)-Fluvastatin D6 (3S,5R)-Fluvastatin D6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. (3S,5R)-Fluvastatin D6 Chemical Structure
  10. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (E/Z)-4-hydroxy Tamoxifen-d5 Chemical Structure
  11. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) Chemical Structure
  12. GC31665 (R)-BPO-27 (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR?inhibitor with an?IC50 of 4 nM. (R)-BPO-27 Chemical Structure
  13. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin is the racemate of Hesperetin. (Rac)-Hesperetin Chemical Structure
  14. GC13136 (S)-Crizotinib Potent MTH1 inhibitor (S)-Crizotinib Chemical Structure
  15. GC14820 (S)-Naproxen (S)-Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. (S)-Naproxen Chemical Structure
  16. GC15015 (±)-Bay K 8644 L-type Ca2+-channel activator (±)-Bay K 8644 Chemical Structure
  17. GC35068 1-Monomyristin A monoacylglycerol 1-Monomyristin Chemical Structure
  18. GC17295 10058-F4 C-Myc-Max dimerization inhibitor 10058-F4 Chemical Structure
  19. GC14918 10074-G5 c-Myc inhibitor 10074-G5 Chemical Structure
  20. GC11720 17-AAG (KOS953) An inhibitor of Hsp90 17-AAG (KOS953) Chemical Structure
  21. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone 2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. 2,3-Dimethoxy-5-methyl-p-benzoquinone Chemical Structure
  22. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO 2,5-Dihydroxycinnamic Acid phenethyl ester Chemical Structure
  23. GC15084 2-Methoxyestradiol (2-MeOE2) A natural metabolite of estradiol 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  24. GC30011 20-Deoxyingenol A diterpenoid with antioxidant and osteoprotective activities 20-Deoxyingenol Chemical Structure
  25. GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene is a Pterostilbene analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 ?M, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer. 3'-Hydroxypterostilbene Chemical Structure
  26. GC12791 3,3'-Diindolylmethane A phytochemical with antiradiation and chemopreventative effects 3,3'-Diindolylmethane Chemical Structure
  27. GC10710 3-Methyladenine

    3-Methyladenine is a classic autophagy inhibitor.

     3-Methyladenine Chemical Structure
  28. GC32767 3BDO A butyrolactone derivative and autophagy inhibitor 3BDO Chemical Structure
  29. GC39658 4,4'-Dimethoxychalcone 4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties. 4,4'-Dimethoxychalcone Chemical Structure
  30. GC42414 4-hydroxy Tolbutamide 4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. 4-hydroxy Tolbutamide Chemical Structure
  31. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin Chemical Structure
  32. GC13104 4E1RCat Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 4E1RCat Chemical Structure
  33. GC30785 4E2RCat 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 4E2RCat Chemical Structure
  34. GC10468 4EGI-1 Competitive eIF4E/eIF4G interaction inhibitor 4EGI-1 Chemical Structure
  35. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride) Chemical Structure
  36. GC10946 5-Azacytidine

    A DNA methyltransferase inhibitor

     5-Azacytidine Chemical Structure
  37. GN10241 5-Methoxypsoralen 5-Methoxypsoralen Chemical Structure
  38. GC16267 6-Hydroxydopamine hydrobromide Oxidopamine (6-OHDA) hydrobromide is an antagonist of the neurotransmitter dopamine. 6-Hydroxydopamine hydrobromide Chemical Structure
  39. GN10228 6-Shogaol 6-Shogaol Chemical Structure
  40. GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor A 484954 Chemical Structure
  41. GC17710 A-317491 A P2X3 and P2X2/3 receptor antagonist A-317491 Chemical Structure
  42. GC35211 A-317491 sodium salt hydrate A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 sodium salt hydrate Chemical Structure
  43. GC15014 A-867744 A positive allosteric modulator of α7 nAChRs A-867744 Chemical Structure
  44. GC11200 A23187

    A23187, free acid is a Ca2+ ionophore

     A23187 Chemical Structure
  45. GC14069 ABT-199 A Bcl-2 inhibitor ABT-199 Chemical Structure
  46. GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737 Chemical Structure
  47. GC15875 ABT-751 (E7010) ABT-751 (E7010)(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 (E7010) Chemical Structure
  48. GC12422 ABT-888 (Veliparib) ABT-888 (Veliparib) Chemical Structure
  49. GC10871 AC 55649 RARβ2 agonist, potent and selective AC 55649 Chemical Structure
  50. GC35228 Aceglutamide Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration. Aceglutamide Chemical Structure
  51. GC11567 Acetazolamide

    carbonic anhydrase (CA) inhibitor

     Acetazolamide Chemical Structure
  52. GC14142 Acetylcholine Chloride Major transmitter at many nervous sites Acetylcholine Chloride Chemical Structure
  53. GC17094 Acitretin

    Metabolite of etretinate

     Acitretin Chemical Structure
  54. GC17113 Acitretin sodium Second-generation, systemic retinoid Acitretin sodium Chemical Structure
  55. GC41242 Acridine Orange Acridine Orange is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc. Acridine Orange Chemical Structure
  56. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein Chemical Structure
  57. GC16866 Actinomycin D

    A DNA-interacting transcription blocker with anti-cancer activity

     Actinomycin D Chemical Structure
  58. GC19019 Acumapimod Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α. Acumapimod Chemical Structure
  59. GC10610 Adapalene RARβ and RARγ agonist Adapalene Chemical Structure
  60. GC14379 Adapalene sodium salt Retinoic acid receptor agonist Adapalene sodium salt Chemical Structure
  61. GC14106 Adenosine nucleoside Adenosine Chemical Structure
  62. GC19729 Adenosine 5′-diphosphoribose sodium Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium Chemical Structure
  63. GC10707 Afatinib dimaleate An inhibitor of EGFR and ErbB2 Afatinib dimaleate Chemical Structure
  64. GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib impurity 11 Chemical Structure
  65. GC35262 Afzelin A polyphenolic glycoside flavone with diverse biological activities Afzelin Chemical Structure
  66. GC13697 AG-1024 Selective IGF-1R inhibitor AG-1024 Chemical Structure
  67. GC13854 AG-490 (Tyrphostin B42) AG-490 (Tyrphostin B42) (Tyrphostin AG-490 (Tyrphostin B42)) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. AG-490 (Tyrphostin B42) Chemical Structure
  68. GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 Chemical Structure
  69. GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. AGN 194078 Chemical Structure
  70. GC12598 AGN 194310 pan-RAR antagonist AGN 194310 Chemical Structure
  71. GC35265 AGN 195183 AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ. AGN 195183 Chemical Structure
  72. GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). AGN 196996 Chemical Structure
  73. GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. AGN 205327 Chemical Structure
  74. GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 Chemical Structure
  75. GC10518 AICAR An activator of AMPK AICAR Chemical Structure
  76. GC10580 AICAR phosphate AMPK activator AICAR phosphate Chemical Structure
  77. GC12646 AL 8697 p38α inhibitor,potent and selective AL 8697 Chemical Structure
  78. GC15451 Aliskiren Aliskiren Chemical Structure
  79. GC13223 Aliskiren Hemifumarate renin inhibitor Aliskiren Hemifumarate Chemical Structure
  80. GN10407 Alisol A Alisol A Chemical Structure
  81. GC14749 ALLO-1 ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. ALLO-1 Chemical Structure
  82. GN10516 Aloeemodin Aloeemodin Chemical Structure
  83. GC14314 Aloperine An alkaloid Aloperine Chemical Structure
  84. GC13664 AM580 Selective RARα agonist AM580 Chemical Structure
  85. GC35322 Amiodarone Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM. Amiodarone Chemical Structure
  86. GC11432 Amiodarone HCl Amiodarone HCl, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ~45 nM. Amiodarone HCl Chemical Structure
  87. GC63316 Ammonium chloride Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride Chemical Structure
  88. GC12326 Amsacrine Topoisomerase 2 inhibitor Amsacrine Chemical Structure
  89. GC11747 Amsacrine hydrochloride Topoisomerase 2 inhibitor Amsacrine hydrochloride Chemical Structure
  90. GN10718 Andrographolide Andrographolide Chemical Structure
  91. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  92. GC14292 Apatinib Mesylate

    Apatinib blocks the downstream signal transduction of VEGF pathway to inhibit neovascularization.

     Apatinib Mesylate Chemical Structure
  93. GN10150 Apigenin

    Apigenin is a competitive CYP2C9 inhibitor with a Ki of 2 μM.

     Apigenin Chemical Structure
  94. GC16237 Apocynin Selective NADPH-oxidase inhibitor Apocynin Chemical Structure
  95. GC65004 Apostatin-1 Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 Chemical Structure
  96. GC14590 AR-42 (OSU-HDAC42)

    HDAC inhibitor,novel and potent

     AR-42 (OSU-HDAC42) Chemical Structure
  97. GC19035 AR7 A retinoic acid receptor α (RARα) antagonist AR7 Chemical Structure
  98. GN10063 Arctigenin Arctigenin Chemical Structure
  99. GC12474 AS-605240 Potent and selective PI 3-Kγ inhibitor AS-605240 Chemical Structure
  100. GC62309 AS1708727 AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively. AS1708727 Chemical Structure
  101. GC19040 AS1842856

    AS1842856 is a cell permeable inhibitor that inhibits Foxo1 transcriptional activity with IC50=33 nM.

     AS1842856 Chemical Structure

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