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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. Product Name Information
  2. GC30761 α-Hydroxylinoleic acid α-Hydroxylinoleic acid (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. α-Hydroxylinoleic acid Chemical Structure
  3. GC46008 (±)-Thalidomide-d4

    N-Phthaloylglutamimide-d4

     An internal standard for the quantification of (±)-thalidomide (±)-Thalidomide-d4 Chemical Structure
  4. GC34960 (+)-Talarozole (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. (+)-Talarozole Chemical Structure
  5. GC10603 (-)-epicatechin gallate

    ECG

     major catechin in green tea (-)-epicatechin gallate Chemical Structure
  6. GC17242 (-)-epigallocatechin

    (-)EGC, epi-Gallocatechin, NSC 674039

     green tea epicatechin (-)-epigallocatechin Chemical Structure
  7. GC14049 (-)-Epigallocatechin gallate (EGCG)

    EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  8. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively. (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) Chemical Structure
  9. GC60395 (3S,5R)-Fluvastatin D6

    (3S,5R)-XU 62-320 free acid D6

     (3S,5R)-Fluvastatin D6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. (3S,5R)-Fluvastatin D6 Chemical Structure
  10. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5

    Afimoxifene-d5, 4-OHT-d5

     An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (E/Z)-4-hydroxy Tamoxifen-d5 Chemical Structure
  11. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) Chemical Structure
  12. GC31665 (R)-BPO-27 (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR?inhibitor with an?IC50 of 4 nM. (R)-BPO-27 Chemical Structure
  13. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin is the racemate of Hesperetin. (Rac)-Hesperetin Chemical Structure
  14. GC73075 (rel)-ML-SI3

    trans-ML-SI3

     (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 Chemical Structure
  15. GC13136 (S)-Crizotinib Potent MTH1 inhibitor (S)-Crizotinib Chemical Structure
  16. GC14820 (S)-Naproxen

    CG 3117, (S)-Naproxen

     (S)-Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. (S)-Naproxen Chemical Structure
  17. GC15015 (±)-Bay K 8644

    SQ 28,873

     L-type Ca2+-channel activator (±)-Bay K 8644 Chemical Structure
  18. GC35068 1-Monomyristin

    MG(14:0/0:0/0:0), 1-Monomyristin

     A monoacylglycerol 1-Monomyristin Chemical Structure
  19. GC17295 10058-F4 10058-F4 is a c-Myc inhibitor that inhibits c-Myc-Max dimerization and prevents transcriptional activation of c-Myc target gene expression. 10058-F4 Chemical Structure
  20. GC14918 10074-G5 c-Myc inhibitor 10074-G5 Chemical Structure
  21. GC11720 17-AAG (KOS953)

    BMS 722782, CP 127374, KOS 953, NSC 330507, Tanespimycin

     17-AAG(Geldanamycin), a natural benzoquinone ansamycin antibiotic, is the first established inhibitor of Hsp90. 17-AAG (KOS953) Chemical Structure
  22. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

    Coenzyme Q0, CoQ0

     2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. 2,3-Dimethoxy-5-methyl-p-benzoquinone Chemical Structure
  23. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO 2,5-Dihydroxycinnamic Acid phenethyl ester Chemical Structure
  24. GC15084 2-Methoxyestradiol (2-MeOE2)

    2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem

     2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor. 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  25. GC30011 20-Deoxyingenol A diterpenoid with antioxidant and osteoprotective activities 20-Deoxyingenol Chemical Structure
  26. GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene is a Pterostilbene analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 ?M, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer. 3'-Hydroxypterostilbene Chemical Structure
  27. GC12791 3,3'-Diindolylmethane

    DIM

     A phytochemical with antiradiation and chemopreventative effects 3,3'-Diindolylmethane Chemical Structure
  28. GC74663 3,4-Dimethoxychalcone 3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone Chemical Structure
  29. GC10710 3-Methyladenine

    3-MA

    3-Methyladenine is a classic autophagy inhibitor.

     3-Methyladenine Chemical Structure
  30. GC32767 3BDO

    3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one

     A butyrolactone derivative and autophagy inhibitor 3BDO Chemical Structure
  31. GC39658 4,4'-Dimethoxychalcone 4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties. 4,4'-Dimethoxychalcone Chemical Structure
  32. GC42414 4-hydroxy Tolbutamide 4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. 4-hydroxy Tolbutamide Chemical Structure
  33. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin Chemical Structure
  34. GC70208 4-Hydroxytolbutamide-d9 4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide-d9 Chemical Structure
  35. GC13104 4E1RCat

    eIF4E/eIF4G Interaction Inhibitor II

     Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 4E1RCat Chemical Structure
  36. GC30785 4E2RCat 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 4E2RCat Chemical Structure
  37. GC10468 4EGI-1

    eIF4E/eIF4G Interaction Inhibitor

     Competitive eIF4E/eIF4G interaction inhibitor 4EGI-1 Chemical Structure
  38. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride) Chemical Structure
  39. GC10946 5-Azacytidine

    Antibiotic U 18496, 5AzaC, Ladakamycin, Mylosar, NSC 102816, NSC 103627, U 18496, WR 183027

     5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively. 5-Azacytidine Chemical Structure
  40. GN10241 5-Methoxypsoralen

    5-Methoxypsoralen, 5-MOP, Heraclin, NSC 95437

     5-Methoxypsoralen Chemical Structure
  41. GC72854 6-CEPN 6-CEPN is a RAS inhibitor. 6-CEPN Chemical Structure
  42. GC16267 6-Hydroxydopamine hydrobromide

    6-hydroxy Dopamine, Oxidopamine, 2,4,5-Trihydroxyphenethylamine

     6-Hydroxydopamine hydrobromide (6-OHDA) is a structural analogue of catecholamines, dopamine and noradrenaline, and exerts its toxic effects on catecholaminergic neurons. 6-Hydroxydopamine hydrobromide Chemical Structure
  43. GN10228 6-Shogaol

    A bioactive component of ginger

     6-Shogaol Chemical Structure
  44. GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor A 484954 Chemical Structure
  45. GC17710 A-317491

    A 317491;A317491

     A P2X3 and P2X2/3 receptor antagonist A-317491 Chemical Structure
  46. GC35211 A-317491 sodium salt hydrate A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 sodium salt hydrate Chemical Structure
  47. GC15014 A-867744 A positive allosteric modulator of α7 nAChRs A-867744 Chemical Structure
  48. GC11200 A23187

    Calcimycin

    A23187, free acid is a Ca2+ ionophore

     A23187 Chemical Structure
  49. GC42677 ABO (hydrochloride) ABO is a modulator of annexin A7. ABO (hydrochloride) Chemical Structure
  50. GC14069 ABT-199

    GDC 0199, Venetoclax

     Venetoclax (ABT-199, GDC-0199) is a selective inhibitor of Bcl-2 with a K i of 0.01 nM in cell-free assays. ABT-199 Chemical Structure
  51. GC17234 ABT-737

    ABT 737, ABT737

     An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737 Chemical Structure
  52. GC15875 ABT-751 (E7010) ABT-751 (E7010)(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 (E7010) Chemical Structure
  53. GC12422 ABT-888 (Veliparib) ABT-888 (Veliparib) Chemical Structure
  54. GC10871 AC 55649 RARβ2 agonist, potent and selective AC 55649 Chemical Structure
  55. GC35228 Aceglutamide

    Aceglutamide, Acetylglutamine, N-acetyl Gln, NSC 186896

     Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration. Aceglutamide Chemical Structure
  56. GC11567 Acetazolamide

    L-579,486, NSC 145177

    carbonic anhydrase (CA) inhibitor

     Acetazolamide Chemical Structure
  57. GC14142 Acetylcholine Chloride

    ACh

     Major transmitter at many nervous sites Acetylcholine Chloride Chemical Structure
  58. GC17094 Acitretin

    all-trans Acitretin, Ro 10-1670, Ro 10-1670/000

    Metabolite of etretinate

     Acitretin Chemical Structure
  59. GC17113 Acitretin sodium Second-generation, systemic retinoid Acitretin sodium Chemical Structure
  60. GC41242 Acridine Orange

    NSC 194350

    Acridine Orange is a cell-penetrating, nucleic acid-selective fluorescent dye.

     Acridine Orange Chemical Structure
  61. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein Chemical Structure
  62. GC16866 Actinomycin D

    Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K

     Actinomycin D (dactinomycin) is a natural chromopeptide isolated from Streptomyces species, and has one heterocyclic chromophore and two cyclic pentapeptide lactone rings. [1] Actinomycin D Chemical Structure
  63. GC19019 Acumapimod

    BCT-197

     Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α. Acumapimod Chemical Structure
  64. GC10610 Adapalene

    CD 271

     RARβ and RARγ agonist Adapalene Chemical Structure
  65. GC14379 Adapalene sodium salt Retinoic acid receptor agonist Adapalene sodium salt Chemical Structure
  66. GC14106 Adenosine

    NSC 7652

     nucleoside Adenosine Chemical Structure
  67. GC19729 Adenosine 5′-diphosphoribose sodium

    ADP ribose sodium

     Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium Chemical Structure
  68. GC10707 Afatinib dimaleate

    Afatinib dimaleate, BIBW 2992, BIBW 2992MA2

     An inhibitor of EGFR and ErbB2 Afatinib dimaleate Chemical Structure
  69. GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib impurity 11 Chemical Structure
  70. GC35262 Afzelin

    Kaempferin, Kaempferol 3-O-rhamnoside, Kaempferol 3-O-α-L-rhamnopyranoside

     A polyphenolic glycoside flavone with diverse biological activities Afzelin Chemical Structure
  71. GC13697 AG-1024

    AGS 200, Tyrphostin AG1024

     AG-1024 is a reversible, competitive and selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 value of 7µM. AG-1024 can inhibit the phosphorylation of insulin receptor (IR) with an IC50 value of 57µM. AG-1024 Chemical Structure
  72. GC13854 AG-490 (Tyrphostin B42)

    Tyrphostin AG-490

     AG-490 (Tyrphostin B42) is EGFR inhibitor with IC50 of 0.1 µM, AG-490 also has an inhibitory effect on JAK2. AG-490 (Tyrphostin B42) Chemical Structure
  73. GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 Chemical Structure
  74. GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. AGN 194078 Chemical Structure
  75. GC12598 AGN 194310

    VTP-194310

     pan-RAR antagonist AGN 194310 Chemical Structure
  76. GC35265 AGN 195183

    IRX-5183; VTP-195183; NRX-195183

     AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ. AGN 195183 Chemical Structure
  77. GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). AGN 196996 Chemical Structure
  78. GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. AGN 205327 Chemical Structure
  79. GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 Chemical Structure
  80. GC10518 AICAR

    Acadesine, AICA-Riboside, NSC 105823

     AICAR (also called acadesine) is a purine nucleoside. AICAR Chemical Structure
  81. GC10580 AICAR phosphate AMPK activator AICAR phosphate Chemical Structure
  82. GC12646 AL 8697 p38α inhibitor,potent and selective AL 8697 Chemical Structure
  83. GC15451 Aliskiren Aliskiren Chemical Structure
  84. GC13223 Aliskiren Hemifumarate

    CGP 60536, SPP 100

     renin inhibitor Aliskiren Hemifumarate Chemical Structure
  85. GN10407 Alisol A Alisol A Chemical Structure
  86. GC14749 ALLO-1 ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif. ALLO-1 Chemical Structure
  87. GN10516 Aloeemodin

    3-Hydroxymethylchrysazine, NSC 38628, Rhabarberone

     Aloeemodin Chemical Structure
  88. GC14314 Aloperine An alkaloid Aloperine Chemical Structure
  89. GC13664 AM580

    CD336, NSC 608001, Ro 406055

     Selective RARα agonist AM580 Chemical Structure
  90. GC72896 AMDE-1 AMDE-1 is a potent autophagy inducer. AMDE-1 Chemical Structure
  91. GC35322 Amiodarone Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM. Amiodarone Chemical Structure
  92. GC11432 Amiodarone HCl Amiodarone HCl, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ~45 nM. Amiodarone HCl Chemical Structure
  93. GC63316 Ammonium chloride Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride Chemical Structure
  94. GC12326 Amsacrine Topoisomerase 2 inhibitor Amsacrine Chemical Structure
  95. GC11747 Amsacrine hydrochloride

    AMSA, m-AMSA, NSC 141549

     Topoisomerase 2 inhibitor Amsacrine hydrochloride Chemical Structure
  96. GN10718 Andrographolide Andrographolide Chemical Structure
  97. GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

    Androkinin, NSC 9898

    An androgenic steroid

     Androsterone (5α-Androstan-3α-ol-17-one) Chemical Structure
  98. GC14292 Apatinib Mesylate

    YN968D1

     Apatinib Mesylate blocks the downstream signal transduction of VEGF pathway to inhibit neovascularization. Apatinib Mesylate Chemical Structure
  99. GN10150 Apigenin

    Chamomile, Flavone, NSC 83244, Versulin

     Apigenin (API), or 4′,5,7-trihydroxyflavone, is a bioactive flavonoid present in many plants, known for its anti-inflammatory, antioxidant, and anticancer properties. Apigenin Chemical Structure
  100. GC16237 Apocynin

    Acetoguaiacone, Acetovanillone, NSC 2146, NSC 209524

     Selective NADPH-oxidase inhibitor Apocynin Chemical Structure
  101. GC65004 Apostatin-1

    Apt-1

     Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 Chemical Structure

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