IF 51
PMID: 39112701 ↗Dopamine
Catalog No.: GC62940Purity:>98.00%Synonyms: DA, 3-hydroxy Tyramine, KW 3160, NSC 173182; 4-(2-Aminoethyl)benzene-1,2-diol
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain.
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Cas No.: 51-61-6
10mgIn Stock
$49.00
1
50mgIn Stock
$122.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mg | $49.00 | In Stock | 1 | |
| 50mg | $122.00 | In Stock | 1 |
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Citations
1 publicationsPublications from researchers using this productDescription
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body[1]. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 µ 24hours)[2].
Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF[2].
[1]. JuÁrez OlguÍn H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467.
[2]. Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7(5):569-74.
Product Documents
Purity:>98.00%Appearance:A solid
Chemical Properties
CAS No.
51-61-6
Synonyms
DA, 3-hydroxy Tyramine, KW 3160, NSC 173182; 4-(2-Aminoethyl)benzene-1,2-diol
Molecular Formula
C8H11NO2
Molecular Weight
153.18
Solubility
DMSO : 100 mg/mL (652.83 mM; Need ultrasonic)
Storage
Store at RT,protect from light, stored under nitrogen
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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