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Dopamine (Synonyms: DA, 3-hydroxy Tyramine, KW 3160, NSC 173182)

Catalog No.GC62940

Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain.

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Dopamine Chemical Structure

Cas No.: 51-61-6

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100 mg
$31.50
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500 mg
$58.50
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body[1]. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 µ 24hours)[2].

Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF[2].

[1]. JuÁrez OlguÍn H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467.
[2]. Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7(5):569-74.

Chemical Properties

Cas No. 51-61-6 SDF
Synonyms DA, 3-hydroxy Tyramine, KW 3160, NSC 173182
Formula C8H11NO2 M.Wt 153.18
Solubility Storage Store at RT,protect from light, stored under nitrogen
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 6.5283 mL 32.6413 mL 65.2827 mL
5 mM 1.3057 mL 6.5283 mL 13.0565 mL
10 mM 0.6528 mL 3.2641 mL 6.5283 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 36 reference(s) in Google Scholar.)

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