GLPBio

DOSEH (chloride)

Catalog No.: GC92041Purity:>95.00%
COASDSData Sheet
DOSEH is a cationic sulfonium lipid that has been used in the generation of sulfonium lipid nanoparticles (sLNPs) for the delivery of mRNA in vivo.

Products are for research use only. Not for human use. We do not sell to patients.

DOSEH (chloride)
5 mgIn Stock
$175.00
1
10 mgIn Stock
$298.00
1
25 mgIn Stock
$700.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

Description

DOSEH is a cationic sulfonium lipid that has been used in the generation of sulfonium lipid nanoparticles (sLNPs) for the delivery of mRNA in vivo.1 LNPs containing DOSEH and encapsulating an mRNA reporter accumulate primarily in the lungs after intravenous administration in mice. DOSEH-containing LNPs encapsulating Cre mRNA induce the expression of tdTomato in the lungs of Ai14 mice engineered to express tdTomato upon Cre-mediated recombination.

References:
[1]. Popoola, D.O., Cao, Z., Men, Y., et al.Lung-specific mRNA delivery enabled by sulfonium lipid nanoparticlesNano Lett.24(26)8080-8088(2024).

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Chemical Name
(2-hydroxyethyl)dioctadecylsulfonium, monochloride
SMILES
CCCCCCCCCCCCCCCCCC[S+](CCO)CCCCCCCCCCCCCCCCCC.[Cl-]
Molecular Formula
C38H79OS ? Cl
Molecular Weight
619.6
Solubility
Acetonitrile: Slightly soluble: 0.1-1 mg/ml,Chloroform: Slightly soluble: 0.1-1 mg/ml
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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