GLPBio

DSPE-Polysarcosine50

Catalog No.: GC91873Purity:>90.00%Synonyms: 1,2-Distearoyl-rac-glycero-3-PE-Polysarcosine50; 1,2-Distearoyl-rac-glycero-3-Phosphatidylethanolamine-Polysarcosine50; 1,2-Distearoyl-rac-glycero-3-Phosphoethanolamine-Polysarcosine50; 1,2-DSPE-Polysarcosine50; DSPE-pSar50
COASDSData Sheet

DSPE-polysarcosine50 is an amine-functionalized hydrophilic polymer.

Products are for research use only. Not for human use. We do not sell to patients.

DSPE-Polysarcosine50
50mgIn Stock
$2,000.00
1
100mgIn Stock
$3,400.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    641, 529–536 (2025)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

DSPE-polysarcosine50 is an amine-functionalized hydrophilic polymer.1 It is a polysarcosine-labeled form of 1,2-distearoyl-rac-glycero-3-PE (DSPE). Polysarcosines have been used as alternatives to PEGylation in lipid nanoparticles (LNPs) and to reduce the immunogenicity of administered proteins in vivo.1,2

References:
[1]. Nogueira, S.S., Schlegel, A., Maxeiner, K., et al.Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA deliveryACS Appl. Nano Mater.3(11)10634-10645(2020).
[2]. Hu, Y., Hou, Y., Wang, H., et al.Polysarcosine as an alternative to PEG for therapeutic protein conjugationBioconjug. Chem.29(7)2232-2238(2018).

Product Documents

Purity:>90.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Synonyms
1,2-Distearoyl-rac-glycero-3-PE-Polysarcosine50; 1,2-Distearoyl-rac-glycero-3-Phosphatidylethanolamine-Polysarcosine50; 1,2-Distearoyl-rac-glycero-3-Phosphoethanolamine-Polysarcosine50; 1,2-DSPE-Polysarcosine50; DSPE-pSar50
Chemical Name
(2R)-3-((hydroxy(2-(2-(N-methyl-2-(methylamino)acetamido)acetamido)ethoxy)phosphoryl)oxy)propane-1,2-diyl distearate
SMILES
CCCCCCCCCCCCCCCCCC(OC[C@H](COP(O)(OCCNC(CN(C)C(CNC)=O)=O)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O
Molecular Formula
(C3H5NO)nC44H87N2O9P
Solubility
Chloroform: Soluble
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion

g/mol

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