GLPBio

E0924G

Catalog No.: GC82887Purity:>99.00%
COASDSData Sheet
E0924G is an orally active activator for PPARδ with EC 50 of 2.82 μM.

Products are for research use only. Not for human use. We do not sell to patients.

E0924G
Cas No.: 2909474-29-7
10mM (in 1mL DMSO)In Stock
$30.00
1
5mgIn Stock
$27.00
1
10mgIn Stock
$43.00
1
25mgIn Stock
$86.00
1
50mgIn Stock
$137.00
1
100mgIn Stock
$216.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    Cell Research
    33, 546–561 (2023)
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    Cell Research
    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

E0924G is an orally active activator for PPARδ with EC 50 of 2.82 μM. E0924G promotes the upregulation of osteoprotegerin (OPG) with an EC 50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibites F-actin ring formation in RAW264.7 macrophages. E0924G regulates the bone density and bone loss in ovariectomized (OVX) and age-related osteoporosis models [1].

References:
[1]. Li Y, et al., The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice. Bioorg Chem. 2024 Jun;147:107364.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2909474-29-7
Molecular Formula
C12H12N2O3
Molecular Weight
232.24
Solubility
DMSO: 100 mg/mL (430.59 mM; Need ultrasonic)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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