GLPBio

PPAR

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The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

Products Related to PPAR(244)

  • GC18151 structure
    GC18151Elafibranor (GFT505)
    CAS: 923978-27-2
    Purity: >99.00%

    Elafibranor (GFT505) (GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively.

  • GC82158 structure
    GC82158Amezalpat
    CAS: 1616372-41-8
    Purity: >99.50%

    Amezalpat is the antagonist for PPARα with IC 50 of 58 nM.

  • GC82298 structure
    GC82298ATRA-biotin
    CAS: 2226143-93-5
    Purity: >98.00%

    ATRA-biotin (Biotin-ATRA-conjugate) is a biotin-conjugated ATRA.

  • GC82590 structure
    GC82590Chiglitazar sodium
    CAS: 2390374-10-2
    Purity: >98.00%

    Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC 50 s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively.

  • GC82675 structure
    GC82675CUDA disodium
    Purity: >98.00%

    CUDA disodium is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC 50 s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively [1] . CUDA disodium selectively increases peroxisome proliferator-activated receptor ( PPAR ) alpha activity.

  • GC82711 structure
    GC82711D-Arabinopyranose- 13 C 5
    Purity: >99.50%

    D-Arabinopyranose - 13 C 5 is the 13 C-labeled D-Arabinopyranose.

  • GC82882 structure
    GC82882(E)-CLX-0921
    CAS: 606932-81-4
    Purity: >98.00%

    (E)-CLX-0921 is the E-isomer of CLX-0921.

  • GC82887 structure
    GC82887E0924G
    CAS: 2909474-29-7
    Purity: >99.00%

    E0924G is an orally active activator for PPARδ with EC 50 of 2.82 μM.

  • GC83042 structure
    GC83042Fmoc-leucine-d 10
    CAS: 1190594-22-9
    Purity: >99.00%

    Fmoc-leucine-d 10 is the deuterium labeled Fmoc-leucine.

  • GC83796 structure
    GC83796Palmitoyllactic acid
    CAS: 7795-58-6
    Purity: >99.50%

    Palmitoyllactic acid is a long-chain fatty acid with lipogenic activity.

  • GC84054 structure
    GC84054Schizophyllan
    CAS: 9050-67-3

    Schizophyllan (SPG) is an orally active extracellular β-glucan produced by the fungus Schizophyllum commune.

  • GC84060 structure
    GC84060Seladelpar (lysine)
    CAS: 928821-41-4
    Purity: >98.00%

    Seladelpar (MBX-8025) lysine is an orally active, potent and specific PPARδ agonist with an EC 50 of 2 nM.

  • GC84088 structure
    GC84088SKLB102
    CAS: 242473-63-8
    Purity: >98.00%

    SKLB102 shows a high affinity with PPARγ. SKLB102 has potent ability to reduce fat deposition and protect liver against non-alcoholic fatty liver disease (NAFLD) through regulating adipocytokine expression and preventing insulin resistance [1] .

  • GC84317 structure
    GC84317Troglitazone-d 4
    CAS: 2749370-85-0
    Purity: >98.00%

    Troglitazone-d 4 is deuterium labeled Troglitazone.

  • GC84861 structure
    GC84861PPARα/γ agonist 1
    Purity: >99.50%

    PPARα/γ agonist 1 (compound 5b) is a potent and dual PPARα/γ partial agonist with EC 50 values of 28 nM and 69 nM for PPARα and PPARγ, respectively.

  • GC84863 structure
    GC8486323-epi-26-Deoxyactein
    CAS: 501938-01-8
    Purity: >98.50%

    23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound [1] [2] [3] .

  • GC10190 structure
    GC10190DG-172 (hydrochloride)
    CAS: 1361504-77-9
    Purity: >99.00%

    DG-172 (hydrochloride) is a selective PPARβ/δ antagonist, with an IC50 of 27 nM.

  • GC10381 structure
    GC10381AUDA
    CAS: 479413-70-2
    Purity: >98.00%

    Potent epoxide hydrolase inhibitor/PPARα activator

  • GC11152 structure
    GC11152Pioglitazone HCl
    CAS: 112529-15-4
    Purity: >99.50%

    A PPARγ agonist

  • GC11170 structure
    GC11170Choline Fenofibrate
    CAS: 856676-23-8
    Purity: >98.00%
  • GC11318 structure
    GC11318Rosiglitazone maleate
    CAS: 155141-29-0
    Purity: >99.50%

    A PPARγ agonist

  • GC11423 structure
    GC11423GW1929
    CAS: 196808-24-9
    Purity: >99.50%

    A non-thiazolidinedione activator of PPARγ

  • GC11477 structure
    GC11477Darglitazone
    CAS: 141200-24-0
    Purity: >99.00%

    PPARγ agonist with antidiabetic actions

  • GC11586 structure
    GC11586SR 202
    CAS: 76541-72-5
    Purity: >99.50%

    SR 202 (SR-202) is a potent and specific PPARγ antagonist.