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Home >> Signaling Pathways >> Metabolism >> PPAR

PPAR

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

Products for  PPAR

  1. Cat.No. Product Name Information
  2. GC39271 (±)-Naringenin A citrusderived flavonoid (±)-Naringenin Chemical Structure
  3. GC46365 1,1'-(Azodicarbonyl)dipiperidine A Mitsunobu reagent 1,1'-(Azodicarbonyl)dipiperidine Chemical Structure
  4. GC48782 10,13-epoxy-11-methyl-Octadecadienoic Acid A furan fatty acid 10,13-epoxy-11-methyl-Octadecadienoic Acid Chemical Structure
  5. GC41867 10-Nitrolinoleate 10-Nitrolinoleate is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleate Chemical Structure
  6. GC41868 10-Nitrooleate 10-Nitrooleate (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles. 10-Nitrooleate Chemical Structure
  7. GC13960 15-deoxy-Δ-12,14-Prostaglandin J2 15-deoxy-Δ-12,14-Prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-deoxy-Δ-12,14-Prostaglandin J2 Chemical Structure
  8. GC46447 15-deoxy-δ12,14-Prostaglandin J2-d4 An internal standard for the quantification of 15deoxyΔ12,14prostaglandin J2 15-deoxy-δ12,14-Prostaglandin J2-d4 Chemical Structure
  9. GC65414 2-(Tetradecylthio)acetic acid 2-Tetradecylthio acetic acid is a pan-peroxisome proliferator activated receptor (pan-PPAR) activator. 2-(Tetradecylthio)acetic acid Chemical Structure
  10. GC12289 3-Thiatetradecanoic Acid activator of PPAR 3-Thiatetradecanoic Acid Chemical Structure
  11. GC35143 4-O-Methyl honokiol A phenol with diverse biological activities 4-O-Methyl honokiol Chemical Structure
  12. GC41530 4-oxo Docosahexaenoic Acid 4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. 4-oxo Docosahexaenoic Acid Chemical Structure
  13. GC63358 5-Aminosalicylic Acid-D3 hydrochloride 5-Aminosalicylic Acid-D3 hydrochloride Chemical Structure
  14. GC46757 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) An isomer of linoleic acid 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) Chemical Structure
  15. GC42649 9-Nitrooleate Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate, cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. 9-Nitrooleate Chemical Structure
  16. GC42651 9-oxo-10(E),12(E)-Octadecadienoic Acid 9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxoODA) is a natural agonist, abundant in tomatoes, that activates PPARα at 10-20 μM. 9-oxo-10(E),12(E)-Octadecadienoic Acid Chemical Structure
  17. GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol Chemical Structure
  18. GN10413 Agrimol B Agrimol B Chemical Structure
  19. GC35281 Aleglitazar Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar Chemical Structure
  20. GC35308 Alpinetin Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity. Alpinetin Chemical Structure
  21. GC62836 AMG131 AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM. AMG131 Chemical Structure
  22. GC40636 Amorfrutin A Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. Amorfrutin A Chemical Structure
  23. GC42791 Amorfrutin B Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. Amorfrutin B Chemical Structure
  24. GC35349 Angeloylgomisin H Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ. Angeloylgomisin H Chemical Structure
  25. GC35358 Ankaflavin Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin Chemical Structure
  26. GC31462 Arhalofenate (MBX 102) Arhalofenate (MBX 102) (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. Arhalofenate (MBX 102) Chemical Structure
  27. GC31350 Astaxanthin Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin Chemical Structure
  28. GC10381 AUDA Potent epoxide hydrolase inhibitor/PPARα activator AUDA Chemical Structure
  29. GC31452 AVE-8134 AVE-8134 is a potent PPARα agonist, with EC50 values of 100 and 3000 nM for human and rodent PPARα receptor, respectively. AVE-8134 Chemical Structure
  30. GC64099 AZD-9574 AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 Chemical Structure
  31. GC42890 Azelaoyl PAF Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. Azelaoyl PAF Chemical Structure
  32. GC13829 BADGE

    PPARγ antagonist

     BADGE Chemical Structure
  33. GC12894 Balaglitazone A partial agonist of PPARγ Balaglitazone Chemical Structure
  34. GC14543 Bezafibrate Lipid-lowering agent Bezafibrate Chemical Structure
  35. GC45726 Bezafibrate-d4 An internal standard for the quantification of bezafibrate Bezafibrate-d4 Chemical Structure
  36. GC35518 Bilobetin A biflavonoid with diverse biological activities Bilobetin Chemical Structure
  37. GC15995 BMS 687453 PPARα agonist BMS 687453 Chemical Structure
  38. GC64699 Bocidelpar Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta (PPAR-δ). Bocidelpar Chemical Structure
  39. GC60675 Caulophyllogenin Caulophyllogenin is a triterpene saponin extracted from M. Caulophyllogenin Chemical Structure
  40. GC40384 CAY10410 CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. CAY10410 Chemical Structure
  41. GC43162 CAY10506 Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 Chemical Structure
  42. GC40764 CAY10514 CAY10514 is an aromatic analog of 8(S)-HETE. CAY10514 Chemical Structure
  43. GC43174 CAY10573 The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 Chemical Structure
  44. GC43180 CAY10592 Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. CAY10592 Chemical Structure
  45. GC18876 CAY10599 Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. CAY10599 Chemical Structure
  46. GC47063 CAY10767 A PPARα agonist CAY10767 Chemical Structure
  47. GC48426 CAY10771 A dual agonist of FXR and PPARδ CAY10771 Chemical Structure
  48. GC32723 CDDO-Im (RTA-403) CDDO-Im (RTA-403) (RTA-403) is an activator of Nrf2 and PPAR, with Kis of 232 and 344 nM for PPARα and PPARγ. CDDO-Im (RTA-403) Chemical Structure
  49. GC61805 Cefminox sodium Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity. Cefminox sodium Chemical Structure
  50. GC16301 Cetaben unique,PPARα-independent peroxisome proliferator Cetaben Chemical Structure
  51. GC31552 Chiglitazar Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively. Chiglitazar Chemical Structure
  52. GC11170 Choline Fenofibrate Choline Fenofibrate Chemical Structure
  53. GC17135 Ciglitazone PPARγ agonist Ciglitazone Chemical Structure
  54. GN10678 Cinnamyl alcohol Cinnamyl alcohol Chemical Structure
  55. GC13633 Ciprofibrate A selective PPARα agonist Ciprofibrate Chemical Structure
  56. GC35698 Ciprofibrate D6 Ciprofibrate D6 is deuterium labeled Ciprofibrate. Ciprofibrate D6 Chemical Structure
  57. GC60710 Ciprofibrate impurity A Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha. Ciprofibrate impurity A Chemical Structure
  58. GC17377 Clofibrate PPAR agonist Clofibrate Chemical Structure
  59. GC49087 Clofibric Acid-d4 An internal standard for the quantification of clofibric acid Clofibric Acid-d4 Chemical Structure
  60. GC39701 Convallatoxin Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin Chemical Structure
  61. GC15673 CP 775146 PPARα agonist CP 775146 Chemical Structure
  62. GN10293 Daidzein Daidzein Chemical Structure
  63. GC11477 Darglitazone PPARγ agonist with antidiabetic actions Darglitazone Chemical Structure
  64. GC10190 DG-172 (hydrochloride) DG-172 (hydrochloride) is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG-172 (hydrochloride) Chemical Structure
  65. GC41492 Edaglitazone Edaglitazone is an agonist of peroxisome proliferator-activated receptor γ (PPARγ). Edaglitazone Chemical Structure
  66. GC38015 Eicosatetraynoic acid A nonspecific inhibitor of cyclooxygenases and lipoxygenases Eicosatetraynoic acid Chemical Structure
  67. GC18151 Elafibranor (GFT505) Elafibranor (GFT505) (GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor (GFT505) Chemical Structure
  68. GC33816 Ertiprotafib (PTP 112) Ertiprotafib (PTP 112) is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. Ertiprotafib (PTP 112) Chemical Structure
  69. GN10511 Eupatilin Eupatilin Chemical Structure
  70. GC62203 Falcarindiol Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol Chemical Structure
  71. GC12250 Fenofibrate

    PPARα agonist

     Fenofibrate Chemical Structure
  72. GC47337 Fenofibrate-d6 An internal standard for the quantification of fenofibrate Fenofibrate-d6 Chemical Structure
  73. GC14584 Fenofibric acid ppar inhibitor， lipid-lowering agent Fenofibric acid Chemical Structure
  74. GC12134 FH535 An inhibitor of β-catenin signaling FH535 Chemical Structure
  75. GN10030 Fisetin Fisetin Chemical Structure
  76. GC62974 FK614 FK614 is an orally active, non-thiazolidinedione (TZD) type, and selective PPARγ modulator (SPPARM). FK614 Chemical Structure
  77. GC33734 Fonadelpar (NPS-005) Fonadelpar (NPS-005) is a PPARδ agonist, used in the research of neuroparalytic keratopathy. Fonadelpar (NPS-005) Chemical Structure
  78. GC15085 G3335 G3335 is a selective, reversible and cell-permeable PPARγ with a Kd of ~8 μM. G3335 Chemical Structure
  79. GC43723 Galactosylsphingosine (d18:1) Galactosylsphingosine (d18:1) (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Galactosylsphingosine (d18:1) Chemical Structure
  80. GC14915 Gemfibrozil PPARα activator Gemfibrozil Chemical Structure
  81. GC43743 Gemfibrozil 1-O-β-Glucuronide Gemfibrozil 1-O-β-glucuronide is a major metabolite of gemfibrozil that is formed when gemfibrozil undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7. Gemfibrozil 1-O-β-Glucuronide Chemical Structure
  82. GC47397 Gemfibrozil-d6 An internal standard for the quantification of gemfibrozil Gemfibrozil-d6 Chemical Structure
  83. GN10538 Ginsenoside Rh1 Ginsenoside Rh1 Chemical Structure
  84. GN10098 Glabridin Glabridin Chemical Structure
  85. GC36146 Glabrone Glabrone is an isoflavone isolated from Glycyrrhiza glabra roots. Glabrone Chemical Structure
  86. GC14531 Glycerophospho-N-Oleoyl Ethanolamine precursor of oleoyl ethanolamide (OEA) Glycerophospho-N-Oleoyl Ethanolamine Chemical Structure
  87. GC11916 GQ-16 partial agonist for PPARγ GQ-16 Chemical Structure
  88. GC17824 GSK 0660 PPARδ antagonist GSK 0660 Chemical Structure
  89. GC31471 GSK376501A GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus. GSK376501A Chemical Structure
  90. GC16009 GSK3787 A selective, irreversible PPARβ/δ antagonist GSK3787 Chemical Structure
  91. GC50019 GW 1929 hydrochloride Selective PPARγ agonist. Orally active GW 1929 hydrochloride Chemical Structure
  92. GC11732 GW 590735 potent and selective agonist of PPARα GW 590735 Chemical Structure
  93. GC14187 GW 6471

    PPARα antagonist

     GW 6471 Chemical Structure
  94. GC18024 GW 7647 PPARα agonist GW 7647 Chemical Structure
  95. GC43800 GW 9578 Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor found predominantly in the liver that is involved in the regulation of lipid homeostasis. GW 9578 Chemical Structure
  96. GC14983 GW0742 A selective agonist of PPARδ GW0742 Chemical Structure
  97. GC11423 GW1929 A non-thiazolidinedione activator of PPARγ GW1929 Chemical Structure
  98. GC15318 GW501516 A selective PPARδ-agonist with anti-obesity activity GW501516 Chemical Structure
  99. GC13969 GW9662

    GW9662 is a specific inhibitor of peroxisome proliferator activated receptor-gamma (PPAR-gamma) with an IC50 of 3.

     GW9662 Chemical Structure
  100. GN10762 Gypenoside XLIX Gypenoside XLIX Chemical Structure
  101. GC40558 Hexanoyl Glycine Hexanoyl glycine is an acylated amino acid that is used as a urinary biomarker for several indications. Hexanoyl Glycine Chemical Structure

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