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Home >> Signaling Pathways >> Metabolism >> PPAR

PPAR

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

Products for  PPAR

  1. Cat.No. Product Name Information
  2. GC91298 (±)-Linalool-d3

    An internal standard for the quantification of (±)-linalool

     (±)-Linalool-d3 Chemical Structure
  3. GC39271 (±)-Naringenin

    SDihydrogenistein, NSC 11855, NSC 34875, Salipurol

     (±)-Naringenin is a flavonoid compound with multiple pharmacological activities including antioxidant, anti-inflammatory, anticancer, cardioprotective and hepatoprotective effects. (±)-Naringenin Chemical Structure
  4. GC40440 (±)8(9)-EET

    (±)8,9EpETrE

     (±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid. (±)8(9)-EET Chemical Structure
  5. GC40838 (±)8(9)-EET methyl ester

    (±)8,9EpETrE methyl ester

     (±)8(9)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450. (±)8(9)-EET methyl ester Chemical Structure
  6. GC46264 (±)8(9)-EET-d11

    (±)8,9-EET-d11, (±)8,9-EpETrE-d11

     A neuropeptide with diverse biological activities (±)8(9)-EET-d11 Chemical Structure
  7. GC45921 (±)8(9)-EET-d11 methyl ester

    (±)8,9-EpETrE-d11 methyl ester

     A neuropeptide with diverse biological activities (±)8(9)-EET-d11 methyl ester Chemical Structure
  8. GC79764 (E/Z)-ABP/PPAR modulator 1 (E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1. (E/Z)-ABP/PPAR modulator 1 Chemical Structure
  9. GC46365 1,1'-(Azodicarbonyl)dipiperidine

    ADDP, NSC 356027

     A Mitsunobu reagent 1,1'-(Azodicarbonyl)dipiperidine Chemical Structure
  10. GC72838 1-Methyladenosine-d3 hydrochloride 1-Metladenosine-d3 drochloride is the drochloride salt form of deuterium labeled 1-Metladenosine. 1-Methyladenosine-d3 hydrochloride Chemical Structure
  11. GC48782 10,13-epoxy-11-methyl-Octadecadienoic Acid

    F2 Furan Fatty Acid, 3-methyl-5-pentyl-2-Furannonanoic Acid, 9M5

    A furan fatty acid

     10,13-epoxy-11-methyl-Octadecadienoic Acid Chemical Structure
  12. GC41867 10-Nitrolinoleate

    10-LNO2, 10nitro9,12Octadecadienoic Acid, 10-NO2-LA

     10-Nitrolinoleate is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleate Chemical Structure
  13. GC41868 10-Nitrooleate

    10Nitrooleic Acid, 10nitro9transOctadecenoic Acid

     10-Nitrooleate (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles. 10-Nitrooleate Chemical Structure
  14. GC40450 15(R)-HETE 15(R)-HETE is produced when aspirin-inhibited COX-2 is incubated with arachidonic acid. 15(R)-HETE Chemical Structure
  15. GC13960 15-deoxy-Δ-12,14-Prostaglandin J2

    15-deoxy-Δ12,14-PGJ2

     15-deoxy-Δ-12,14-Prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-deoxy-Δ-12,14-Prostaglandin J2 Chemical Structure
  16. GC41102 15-deoxy-δ12,14-Prostaglandin D2

    15deoxyΔ12,14PGD2

     15-deoxy-δ12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-δ12,14-PGJ2. 15-deoxy-δ12,14-Prostaglandin D2 Chemical Structure
  17. GC46443 15-deoxy-δ12,14-Prostaglandin D2-d4

    15-deoxy-Δ12,14-PGD2-d4

     A neuropeptide with diverse biological activities 15-deoxy-δ12,14-Prostaglandin D2-d4 Chemical Structure
  18. GC46444 15-deoxy-δ12,14-Prostaglandin D2-d9

    15-deoxy-Δ12,14-PGD2-d9

     A neuropeptide with diverse biological activities 15-deoxy-δ12,14-Prostaglandin D2-d9 Chemical Structure
  19. GC46447 15-deoxy-δ12,14-Prostaglandin J2-d4

    15deoxyΔ12,14PGJ2d4

     An internal standard for the quantification of 15deoxyΔ12,14prostaglandin J2 15-deoxy-δ12,14-Prostaglandin J2-d4 Chemical Structure
  20. GC46448 15-deoxy-δ12,14-Prostaglandin J2-d9

    15-deoxy-Δ12,14-PGJ2-d9

     A neuropeptide with diverse biological activities 15-deoxy-δ12,14-Prostaglandin J2-d9 Chemical Structure
  21. GC65414 2-(Tetradecylthio)acetic acid 2-Tetradecylthio acetic acid is a pan-peroxisome proliferator activated receptor (pan-PPAR) activator. 2-(Tetradecylthio)acetic acid Chemical Structure
  22. GC74164 25-Hydroxytachysterol3

    25-droxytacsterol3 is the metabolite of Vitamin D3.

     25-Hydroxytachysterol3 Chemical Structure
  23. GC12289 3-Thiatetradecanoic Acid

    3-TDA

     activator of PPAR 3-Thiatetradecanoic Acid Chemical Structure
  24. GC35143 4-O-Methyl honokiol

    NSC 293101, 4-Methoxyhonokiol

     A phenol with diverse biological activities 4-O-Methyl honokiol Chemical Structure
  25. GC41530 4-oxo Docosahexaenoic Acid

    4-oxo DHA

     4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. 4-oxo Docosahexaenoic Acid Chemical Structure
  26. GC73301 5-Aminosalicylic acid-d3

    Mesalamine-d3; 5-ASA-d3; Mesalazine-d3

     5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid-d3 Chemical Structure
  27. GC63358 5-Aminosalicylic Acid-D3 hydrochloride 5-Aminosalicylic Acid-D3 hydrochloride Chemical Structure
  28. GC46757 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

    cis-9,trans-11-Conjugated Linoleic Acid, 9(Z),11(E)-CLA

     An isomer of linoleic acid 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) Chemical Structure
  29. GC42649 9-Nitrooleate

    9Nitrooleic Acid, 9nitro9transOctadecenoic Acid

     Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate, cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. 9-Nitrooleate Chemical Structure
  30. GC42651 9-oxo-10(E),12(E)-Octadecadienoic Acid

    9-oxo ODA

     9-oxo-10(E),12(E)-Octadecadienoic acid (9-oxoODA) is a natural agonist, abundant in tomatoes, that activates PPARα at 10-20 μM. 9-oxo-10(E),12(E)-Octadecadienoic Acid Chemical Structure
  31. GC78965 ACT001 hydrochloride

    Dimethylaminomicheliolide hydrochloride; DMAMCL hydrochloride

     ACT001 (Dimethylaminomicheliolide; DMAMCL) hydrochloride is an orally active, blood-brain barrier-permeable anti-inflammatory and anti-tumor agent. ACT001 hydrochloride Chemical Structure
  32. GC31693 Adelmidrol Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ. Adelmidrol Chemical Structure
  33. GN10413 Agrimol B Agrimol B Chemical Structure
  34. GC35281 Aleglitazar Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar Chemical Structure
  35. GC35308 Alpinetin Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity. Alpinetin Chemical Structure
  36. GC62836 AMG131 AMG131 (INT131), a potent and highly selective PPARγ partial agonist, binds to PPARγ and displaces Rosiglitazone with a Ki of ~10 nM. AMG131 Chemical Structure
  37. GC40636 Amorfrutin A

    Amorfrutin 1

     Amorfrutin A is an isoprenoid-substituted benzoic acid natural product found in the fruit of A. Amorfrutin A Chemical Structure
  38. GC42791 Amorfrutin B Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. Amorfrutin B Chemical Structure
  39. GC80865 Anandamide- 15 N

    AEA- 15 NN; Arachidonoyl ethanolamide- 15 NN

     Anandamide - 15 N (AEA- 15 N) is the 15 N-labeled Anandamide. Anandamide- 15 N Chemical Structure
  40. GC35349 Angeloylgomisin H Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ. Angeloylgomisin H Chemical Structure
  41. GC35358 Ankaflavin Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin Chemical Structure
  42. GC73581 Anti-NASH agent 1 Anti-NASH agent 1 (compound 3d)，a derivative of Elafibranor ，is a potent agonist of PPAR-α/δ，targeting to nonalcoholic steatohepatitis (NASH). Anti-NASH agent 1 Chemical Structure
  43. GC31462 Arhalofenate (MBX 102)

    JNJ-39659100, MBX-102

     Arhalofenate (MBX 102) (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. Arhalofenate (MBX 102) Chemical Structure
  44. GC31350 Astaxanthin Astaxanthin is a natural ketolutenoid and a potent antioxidant. Astaxanthin Chemical Structure
  45. GC10381 AUDA Potent epoxide hydrolase inhibitor/PPARα activator AUDA Chemical Structure
  46. GC31452 AVE-8134 AVE-8134 is a potent PPARα agonist, with EC50 values of 100 and 3000 nM for human and rodent PPARα receptor, respectively. AVE-8134 Chemical Structure
  47. GC64099 AZD-9574 AZD-9574 is a novel, blood-brain barrier permeable PARP1 inhibitor that selectively inhibits PARP1 at single-strand break (SSB) sites. AZD-9574 Chemical Structure
  48. GC42890 Azelaoyl PAF Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. Azelaoyl PAF Chemical Structure
  49. GC13829 BADGE

    Bisphenol A diglycidyl ether, DGEBA, NSC 5022

    PPARγ antagonist

     BADGE Chemical Structure
  50. GC12894 Balaglitazone

    DRF 2593

     A partial agonist of PPARγ Balaglitazone Chemical Structure
  51. GC68730 BAY-0069

    BAY-0069 is an effective and selective PPARγ inverse agonist with IC50 values of 6.3 nM for human PPARγ and 24 nM for mouse PPARγ. BAY-0069 can be used in cancer research.

     BAY-0069 Chemical Structure
  52. GC68736 BAY-4931

    BAY-4931 is an effective, covalent, selective PPARγ inverse agonist with an IC50 of 0.17 nM.

     BAY-4931 Chemical Structure
  53. GC73857 BAY-5516 BAY-5516 is a inverse-agonist o PPARG, with the IC50 value of 6.1±3.6 nM that has anti-tumor effect. BAY-5516 Chemical Structure
  54. GC14543 Bezafibrate

    Benzofibrate, BM 15075

     Lipid-lowering agent Bezafibrate Chemical Structure
  55. GC45726 Bezafibrate-d4

    Benzofibrate-d4

     An internal standard for the quantification of bezafibrate Bezafibrate-d4 Chemical Structure
  56. GC68756 Bezafibrate-d6

    Bezafibrate-d6 is the deuterated form of Bezafibrate. Bezafibrate is a PPAR agonist with EC50 values of 50 μM, 60 μM, 20 μM and 90 μM for human and mouse PPARα, PPARγ and PPARδ respectively; it is also a lipid-lowering agent.

     Bezafibrate-d6 Chemical Structure
  57. GC79762 BGT-002

    326E

     BGT-002 (326E) is an orally active dual ACLY inhibitor and PPARα agonist. BGT-002 Chemical Structure
  58. GC35518 Bilobetin A biflavonoid with diverse biological activities Bilobetin Chemical Structure
  59. GC15995 BMS 687453 PPARα agonist BMS 687453 Chemical Structure
  60. GC64699 Bocidelpar

    ASP0367; MA-0211

     Bocidelpar is a modulator of peroxisome proliferator-activated receptor delta (PPAR-δ). Bocidelpar Chemical Structure
  61. GC60675 Caulophyllogenin Caulophyllogenin is a triterpene saponin extracted from M. Caulophyllogenin Chemical Structure
  62. GC40384 CAY10410

    9,10dihydro15deoxyΔ12,14PGJ2, 9,10dihydro15deoxyΔ12,14Prostaglandin J2

     CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. CAY10410 Chemical Structure
  63. GC43162 CAY10506 Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 Chemical Structure
  64. GC40764 CAY10514

    Methyl8hydroxy8(2pentyloxyphenyl)oct5ynoate

     CAY10514 is an aromatic analog of 8(S)-HETE. CAY10514 Chemical Structure
  65. GC43174 CAY10573 The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 Chemical Structure
  66. GC43180 CAY10592 Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. CAY10592 Chemical Structure
  67. GC18876 CAY10599 Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo. CAY10599 Chemical Structure
  68. GC47063 CAY10767 A PPARα agonist CAY10767 Chemical Structure
  69. GC48426 CAY10771 A dual agonist of FXR and PPARδ CAY10771 Chemical Structure
  70. GC70491 CC618 CC618 is a selective peroxisome proliferator-activated receptor (PPARβ/δ) antagonist that exhibits antagonism by covalently binding to PPARβ/δ receptors. CC618 Chemical Structure
  71. GC80481 CCT-010354 CCT-010354 (Compound 63e) is an agent intermediate that can be used to synthesize PPARα/δ dual agonist [1]. CCT-010354 Chemical Structure
  72. GC32723 CDDO-Im (RTA-403)

    CDDO-Imidazolide, RTA 403

     CDDO-Im (RTA-403) is a synthetic triterpenoid that activates Nuclear factor erythroid 2–related factor 2 (Nrf2) signaling by binding to Kelch-like ECH-associated protein 1 (Keap1), thereby inhibiting Nrf2 degradation and increasing its protein levels. CDDO-Im (RTA-403) Chemical Structure
  73. GC61805 Cefminox sodium Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity. Cefminox sodium Chemical Structure
  74. GC16301 Cetaben

    Hexadecylamino-p-amino Benzoic Acid

     unique,PPARα-independent peroxisome proliferator Cetaben Chemical Structure
  75. GC31552 Chiglitazar

    Carfloglitazar

     Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively. Chiglitazar Chemical Structure
  76. GC11170 Choline Fenofibrate Choline Fenofibrate Chemical Structure
  77. GC17135 Ciglitazone

    ADD 3878, U63287

     PPARγ agonist Ciglitazone Chemical Structure
  78. GN10678 Cinnamyl alcohol Cinnamyl alcohol Chemical Structure
  79. GC13633 Ciprofibrate

    (±)-Ciprofibrate, WIN 35,833

     A selective PPARα agonist Ciprofibrate Chemical Structure
  80. GC35698 Ciprofibrate D6

    (±)-Ciprofibrate-d6, WIN 35,833-d6

     Ciprofibrate D6 is deuterium labeled Ciprofibrate. Ciprofibrate D6 Chemical Structure
  81. GC60710 Ciprofibrate impurity A Ciprofibrate impurity A is an impurity of Ciprofibrate. Ciprofibrate (Win35833) is a potent peroxisome proliferator, increases the phosphorylation level of the PPARalpha. Ciprofibrate impurity A Chemical Structure
  82. GC17377 Clofibrate

    ICI 28257, NSC 79389

     PPAR agonist Clofibrate Chemical Structure
  83. GC49087 Clofibric Acid-d4

    Chlorofibrinic acid-d4

     An internal standard for the quantification of clofibric acid Clofibric Acid-d4 Chemical Structure
  84. GC39701 Convallatoxin Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin enhances myocardial contractility by inhibiting Na⁺/K⁺-ATPase to increase intracellular calcium concentration. Convallatoxin Chemical Structure
  85. GC15673 CP 775146 PPARα agonist CP 775146 Chemical Structure
  86. GN10293 Daidzein Daidzein is a natural phytoestrogen isoflavone. Daidzein serves as a PPAR activator. Daidzein Chemical Structure
  87. GC11477 Darglitazone

    CP 86,325

     PPARγ agonist with antidiabetic actions Darglitazone Chemical Structure
  88. GC10190 DG-172 (hydrochloride) DG-172 (hydrochloride) is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG-172 (hydrochloride) Chemical Structure
  89. GC91933 E17241

    4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide

     E17241 is an inducer of the expression of ABCA1, the gene encoding ATP-binding cassette transporter 1; subfamily A (ABCA1). E17241 Chemical Structure
  90. GC41492 Edaglitazone

    BM 13.1258

     Edaglitazone is an agonist of peroxisome proliferator-activated receptor γ (PPARγ). Edaglitazone Chemical Structure
  91. GC38015 Eicosatetraynoic acid A nonspecific inhibitor of cyclooxygenases and lipoxygenases Eicosatetraynoic acid Chemical Structure
  92. GC79120 EL244 EL244 is a dua Autotaxin ( ATX ) ( IC50 = 50 nM) inhibitor and PPARγ ( IC50 = 1.3 μM; K d = 1.3 μM) agonist. EL244 Chemical Structure
  93. GC18151 Elafibranor (GFT505)

    GFT505

     Elafibranor (GFT505) (GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. Elafibranor (GFT505) Chemical Structure
  94. GC33816 Ertiprotafib (PTP 112)

    PTP 112

     Ertiprotafib (PTP 112) is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ. Ertiprotafib (PTP 112) Chemical Structure
  95. GN10511 Eupatilin

    NSC 122413

     Eupatilin is a natural flavonoid compound with multiple biological activities. It is an agonist of peroxisome proliferator-activated receptor α (PPARα) and has anti-apoptotic, antioxidant, and anti-inflammatory effects. Eupatilin Chemical Structure
  96. GC62203 Falcarindiol

    Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells.

     Falcarindiol Chemical Structure
  97. GC12250 Fenofibrate

    PPARα agonist

     Fenofibrate Chemical Structure
  98. GC47337 Fenofibrate-d6 An internal standard for the quantification of fenofibrate Fenofibrate-d6 Chemical Structure
  99. GC14584 Fenofibric acid

    FNF Acid, NSC 281318, Procetofenic Acid

     ppar inhibitor， lipid-lowering agent Fenofibric acid Chemical Structure
  100. GC12134 FH535 An inhibitor of β-catenin signaling FH535 Chemical Structure
  101. GN10030 Fisetin

    CI-75620, NSC 407010, NSC 656275

     Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities. Fisetin Chemical Structure

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