GLPBio

E3 Ligase

E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.

Products Related to E3 Ligase(7)

  • GC10940 structure
    GC10940PRT 4165
    CAS: 31083-55-3
    Purity: >98.50%

    Bmi1/Ring1A-mediated ubiquitination inhibitor

  • GC11869 structure
    GC11869SZL P1-41
    CAS: 222716-34-9
    Purity: >98.00%

    SZL P1-41 is a specific inhibitor of S phase kinase-associated protein 2 (Skp2).

  • GC15017 structure
    GC15017NSC 624206
    CAS: 13116-77-3
    Purity: >98%

    Ubiquitin-activating enzyme (E1) inhibitor

  • GC15492 structure
    GC15492SMER 3
    CAS: 67200-34-4
    Purity: >98.00%

    SMER 3 is a small-molecule compound that selectively inhibits the SCFMet30 ubiquitin E3 ligase.

  • GC25019 structure
    GC250195-amino-2,4-dimethylpyridine (5A-DMP)
    CAS: 1193-71-1
    Purity: >98%
  • GC44291 structure
    GC44291NAB 2
    CAS: 1504588-00-4
    Purity: >98.00%

    NAB 2 is an inhibitor of α-synuclein-induced toxicity.

  • GC50234 structure
    GC50234N106
    CAS: 862974-25-2
    Purity: >98%

    Activator of SUMO-activating enzyme, E1 ligase