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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC68437 Vimentin-IN-1 Vimentin-IN-1 Chemical Structure
  3. GC68146 Xylitol-5-13C Xylitol-5-13C Chemical Structure
  4. GC67908 Calpain-2-IN-1 Calpain-2-IN-1 Chemical Structure
  5. GC52477 Corynoxine (hydrochloride) An indole alkaloid Corynoxine (hydrochloride) Chemical Structure
  6. GC52467 Cell Death Screening Library For screening a variety of cell death pathways Cell Death Screening Library Chemical Structure
  7. GC52447 Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) A fluorogenic substrate for the 20S proteasome and calpains Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt) Chemical Structure
  8. GC52272 Jun9-72-2 A SARS-CoV-2 PLpro inhibitor Jun9-72-2 Chemical Structure
  9. GC65938 Thrombin inhibitor 5 Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor, with IC50s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for research of venous thromboembolism. Thrombin inhibitor 5 Chemical Structure
  10. GC65668 5-Amino-8-hydroxyquinoline 5-Amino-8-hydroxyquinoline (5A8HQ), a potential anticancer candidate, has promising proteasome inhibitory activity. 5-Amino-8-hydroxyquinoline Chemical Structure
  11. GC65575 Cabazitaxel-d6 Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel-d6 Chemical Structure
  12. GC65547 (1S,2R)-Alicapistat (1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD). (1S,2R)-Alicapistat Chemical Structure
  13. GC65540 eIF4A3-IN-2 eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM. eIF4A3-IN-2 Chemical Structure
  14. GC65432 LV-320 LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5??M and a Kd of 16??M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 Chemical Structure
  15. GC65386 Trimetazidine-d8 dihydrochloride Trimetazidine-d8 dihydrochloride is the deuterium labeled Trimetazidine dihydrochloride. Trimetazidine-d8 dihydrochloride Chemical Structure
  16. GC65331 IZCZ-3 IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity. IZCZ-3 Chemical Structure
  17. GC65318 BOLD-100 BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. BOLD-100 Chemical Structure
  18. GC65307 S130 S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 ?M. S130 suppresses autophagy flux. S130 Chemical Structure
  19. GC65297 MW-150 MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 Chemical Structure
  20. GC65191 DC-LC3in-D5 DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 Chemical Structure
  21. GC65115 mTOR inhibitor-1 mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy. mTOR inhibitor-1 Chemical Structure
  22. GC65106 Pregnenolone-d4-1 Pregnenolone-d4-1 Chemical Structure
  23. GC65072 Niacin-13C6 Niacin-13C6 Chemical Structure
  24. GC65010 Bortezomib-d8 Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity. Bortezomib-d8 Chemical Structure
  25. GC65004 Apostatin-1 Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 Chemical Structure
  26. GC64694 UPCDC-30245 UPCDC-30245 is an allosteric p97 inhibitor with an IC50 of approximately 27 nM. UPCDC-30245 inhibits the p97 mutant N660K similar to wild type (WT; IC50=300 nM) and shows 3-fold resistance for p97 mutant T688A. UPCDC-30245 can be used in the research of cancer. UPCDC-30245 Chemical Structure
  27. GC64607 Dazcapistat Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively (patent WO2018064119A1, compound 405). Dazcapistat Chemical Structure
  28. GC64524 Clematichinenoside AR Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS). Clematichinenoside AR Chemical Structure
  29. GC64472 20S Proteasome-IN-1 20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2. 20S Proteasome-IN-1 Chemical Structure
  30. GC52057 QN523 An anticancer agent QN523 Chemical Structure
  31. GC64378 Valproic acid-d6 Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid-d6 Chemical Structure
  32. GC64363 Lumefantrine-d9 Lumefantrine-d9 Chemical Structure
  33. GC64358 Olacaftor Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408. Olacaftor Chemical Structure
  34. GC64325 Ligustilide Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide Chemical Structure
  35. GC64282 LXE408 LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 Chemical Structure
  36. GC64223 Sophocarpine monohydrate Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine monohydrate Chemical Structure
  37. GC64213 GSK3494245 GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. GSK3494245 Chemical Structure
  38. GC64136 Desmethyl Naproxen-d3 Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen. Desmethyl Naproxen-d3 Chemical Structure
  39. GC64113 Lamotrigine-13C3,d3 Lamotrigine-13C3,d3 Chemical Structure
  40. GC64098 Isoniazid-d4 Isoniazid-d4 Chemical Structure
  41. GC64076 Nortriptyline Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline Chemical Structure
  42. GC64070 Omeprazole-d3-1 Omeprazole-d3-1 Chemical Structure
  43. GC64032 Salicylic acid-d6 Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid. Salicylic acid-d6 Chemical Structure
  44. GC64013 ZX-29 ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect. ZX-29 Chemical Structure
  45. GC64003 Carvedilol-d4 Carvedilol-d4 Chemical Structure
  46. GC63964 PR-39 TFA PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFA Chemical Structure
  47. GC63840 Tat-beclin 1 Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 Chemical Structure
  48. GC63827 Atropine sulfate monohydrate Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect. Atropine sulfate monohydrate Chemical Structure
  49. GC49670 Indium (III) thiosemicarbazone 5b An anticancer agent Indium (III) thiosemicarbazone 5b Chemical Structure
  50. GC63601 Trimetazidine Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine Chemical Structure
  51. GC63515 Hoechst 33342 Hoechst 33342 is a DNA minor groove binder used fluorochrome for visualizing cellular DNA. Hoechst 33342 Chemical Structure
  52. GC63316 Ammonium chloride Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride Chemical Structure
  53. GC62881 CA77.1 CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 Chemical Structure
  54. GC62853 Aumitin Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin Chemical Structure
  55. GC49341 Spermidine-d6 An internal standard for the quantification of spermidine Spermidine-d6 Chemical Structure
  56. GC49308 Ungeremine A betaine-type alkaloid with diverse biological activities Ungeremine Chemical Structure
  57. GC49241 Methyl Diethyldithiocarbamate An active metabolite of disulfiram Methyl Diethyldithiocarbamate Chemical Structure
  58. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (E/Z)-4-hydroxy Tamoxifen-d5 Chemical Structure
  59. GC49124 EN219 EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination. EN219 Chemical Structure
  60. GC49084 PHY34 An inhibitor of late-stage autophagy PHY34 Chemical Structure
  61. GC49016 Dimethyl 2-ketoglutarate An esterified form of α-ketoglutarate Dimethyl 2-ketoglutarate Chemical Structure
  62. GC62637 AUTAC4 AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 Chemical Structure
  63. GC62630 TAS-117 hydrochloride TAS-117 hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 hydrochloride induces apoptosis and autophagy. TAS-117 hydrochloride Chemical Structure
  64. GC62626 ICCB-19 hydrochloride ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride Chemical Structure
  65. GC62564 Mito-LND Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells. Mito-LND Chemical Structure
  66. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin is the racemate of Hesperetin. (Rac)-Hesperetin Chemical Structure
  67. GC62465 Idelalisib D5 Idelalisib D5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor. Idelalisib D5 Chemical Structure
  68. GC62399 RA375 RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead. RA375 Chemical Structure
  69. GC62339 mTOR inhibitor-8 mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells. mTOR inhibitor-8 Chemical Structure
  70. GC62309 AS1708727 AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively. AS1708727 Chemical Structure
  71. GC62239 Zetomipzomib Zetomipzomib (KZR-616), a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. Zetomipzomib Chemical Structure
  72. GC62210 ONX-0914 TFA ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA Chemical Structure
  73. GC62203 Falcarindiol Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol Chemical Structure
  74. GC62193 (1S,2S)-Bortezomib (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans. (1S,2S)-Bortezomib Chemical Structure
  75. GC62146 XST-14 XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects. XST-14 Chemical Structure
  76. GC62135 BC1618 BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 Chemical Structure
  77. GC61945 PR-924 PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 Chemical Structure
  78. GC61865 Cearoin Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK. Cearoin Chemical Structure
  79. GC19766 Heparin sodium salt (MW 15kDa)

    A polymer of Heparin with the molecular weight of 15kD

     Heparin sodium salt (MW 15kDa) Chemical Structure
  80. GC61809 Olanzapine D3 Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine. Olanzapine D3 Chemical Structure
  81. GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds. Ethyl 3,4-dihydroxybenzoate Chemical Structure
  82. GC61565 Indophagolin Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7. Indophagolin Chemical Structure
  83. GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. Calmodulin-Dependent Protein Kinase II(290-309) acetate Chemical Structure
  84. GC61520 Cilengitide TFA Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. Cilengitide TFA Chemical Structure
  85. GC61472 Zingiberene Zingiberene (α-Zingiberene) is a monocyclic sesquiterpene which is the predominant constituent of ginger with oil content (Zingiber officinale). Neuroprotective potential. Zingiberene triggers autophagy. Anticancer activity. Zingiberene Chemical Structure
  86. GC19729 Adenosine 5′-diphosphoribose sodium Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium Chemical Structure
  87. GC48689 SBP-7455 A dual inhibitor of ULK1 and ULK2 SBP-7455 Chemical Structure
  88. GC48676 Monascuspiloin A fungal metabolite with anticancer activity Monascuspiloin Chemical Structure
  89. GC48614 IMP-1710 A clickable UCH-L1 inhibitor IMP-1710 Chemical Structure
  90. GC48595 Chenodeoxycholic Acid MaxSpec® Standard A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications Chenodeoxycholic Acid MaxSpec® Standard Chemical Structure
  91. GC48410 VH 032 Linker 3 (hydrate) A VHL ligand 1 derivative VH 032 Linker 3 (hydrate) Chemical Structure
  92. GC48406 PSI (trifluoroacetate salt) A proteasome inhibitor PSI (trifluoroacetate salt) Chemical Structure
  93. GC19569 Hydroquinone Hydroquinone Chemical Structure
  94. GC48124 Tamoxifen-d5 An internal standard for the quantification of tamoxifen Tamoxifen-d5 Chemical Structure
  95. GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib Sunitinib-d10 Chemical Structure
  96. GC48052 Rilmenidine-d4 An internal standard for the quantification of rilmenidine Rilmenidine-d4 Chemical Structure
  97. GC48027 Rapamycin-d3 An internal standard for the quantification of rapamycin Rapamycin-d3 Chemical Structure
  98. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide Pomalidomide-d5 Chemical Structure
  99. GC47735 N-acetyl Desethylchloroquine-d4 An internal standard for the quantification of N-acetyl desethylchloroquine N-acetyl Desethylchloroquine-d4 Chemical Structure
  100. GC47445 Hydroxychloroquine-d4 (sulfate) An internal standard for the quantification of hydroxychloroquine Hydroxychloroquine-d4 (sulfate) Chemical Structure
  101. GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin HT-2 Toxin-13C22 Chemical Structure

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