Ubiquitination/ Proteasome
- Autophagy(1072)
- DUB(17)
- E1 Activating(1)
- E2 conjugating(1)
- E3 Ligase(6)
- Proteasome(65)
- p97(10)
- Mitophagy(77)
- ULK(9)
- Cat.No. Product Name Information
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GC68437
Vimentin-IN-1
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GC68146
Xylitol-5-13C
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GC67908
Calpain-2-IN-1
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GC52477
Corynoxine (hydrochloride)
An indole alkaloid
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GC52467
Cell Death Screening Library
For screening a variety of cell death pathways
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GC52447
Suc-Leu-Leu-Val-Tyr-AMC (trifluoroacetate salt)
A fluorogenic substrate for the 20S proteasome and calpains
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GC52272
Jun9-72-2
A SARS-CoV-2 PLpro inhibitor
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GC65938
Thrombin inhibitor 5
Thrombin inhibitor 5 (compound 385) is a thrombin inhibitor, with IC50s ranging from 0.1 μM to 1 μM. Thrombin inhibitor 5 can be used for research of venous thromboembolism.
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GC65668
5-Amino-8-hydroxyquinoline
5-Amino-8-hydroxyquinoline (5A8HQ), a potential anticancer candidate, has promising proteasome inhibitory activity.
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GC65575
Cabazitaxel-d6
Cabazitaxel-d6 (XRP6258-d6) is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
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GC65547
(1S,2R)-Alicapistat
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD).
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GC65540
eIF4A3-IN-2
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM.
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GC65432
LV-320
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5??M and a Kd of 16??M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo.
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GC65386
Trimetazidine-d8 dihydrochloride
Trimetazidine-d8 dihydrochloride is the deuterium labeled Trimetazidine dihydrochloride.
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GC65331
IZCZ-3
IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity.
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GC65318
BOLD-100
BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution.
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GC65307
S130
S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 ?M. S130 suppresses autophagy flux.
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GC65297
MW-150
MW150 (MW01-18-150SRM) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.
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GC65191
DC-LC3in-D5
DC-LC3in-D5 acts as an autophagy inhibitor by attenuating LC3B lipidation.
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GC65115
mTOR inhibitor-1
mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.
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GC65106
Pregnenolone-d4-1
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GC65072
Niacin-13C6
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GC65010
Bortezomib-d8
Bortezomib-d8 (PS-341-d8) is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity.
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GC65004
Apostatin-1
Apostatin-1 (Apt-1) is a potent TRADD inhibitor.
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GC64694
UPCDC-30245
UPCDC-30245 is an allosteric p97 inhibitor with an IC50 of approximately 27 nM. UPCDC-30245 inhibits the p97 mutant N660K similar to wild type (WT; IC50=300 nM) and shows 3-fold resistance for p97 mutant T688A. UPCDC-30245 can be used in the research of cancer.
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GC64607
Dazcapistat
Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively (patent WO2018064119A1, compound 405).
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GC64524
Clematichinenoside AR
Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS).
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GC64472
20S Proteasome-IN-1
20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2.
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GC52057
QN523
An anticancer agent
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GC64378
Valproic acid-d6
Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches.
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GC64363
Lumefantrine-d9
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GC64358
Olacaftor
Olacaftor (VX-440) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator extracted from patent US9782408.
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GC64325
Ligustilide
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong.
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GC64282
LXE408
LXE408 is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor.
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GC64223
Sophocarpine monohydrate
Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory.
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GC64213
GSK3494245
GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L.
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GC64136
Desmethyl Naproxen-d3
Desmethyl Naproxen-d3 is deuterium labeled Desmethyl Naproxen.
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GC64113
Lamotrigine-13C3,d3
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GC64098
Isoniazid-d4
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GC64076
Nortriptyline
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression.
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GC64070
Omeprazole-d3-1
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GC64032
Salicylic acid-d6
Salicylic acid-D6 (2-Hydroxybenzoic acid-D6) is a deuterium labeled Salicylic acid.
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GC64013
ZX-29
ZX-29 is a potent and selective ALK inhibitor with an IC50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect.
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GC64003
Carvedilol-d4
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GC63964
PR-39 TFA
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor.
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GC63840
Tat-beclin 1
Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2).
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GC63827
Atropine sulfate monohydrate
Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect.
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GC49670
Indium (III) thiosemicarbazone 5b
An anticancer agent
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GC63601
Trimetazidine
Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA).
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GC63515
Hoechst 33342
Hoechst 33342 is a DNA minor groove binder used fluorochrome for visualizing cellular DNA.
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GC63316
Ammonium chloride
Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor.
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GC62881
CA77.1
CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics.
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GC62853
Aumitin
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I.
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GC49341
Spermidine-d6
An internal standard for the quantification of spermidine
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GC49308
Ungeremine
A betaine-type alkaloid with diverse biological activities
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GC49241
Methyl Diethyldithiocarbamate
An active metabolite of disulfiram
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GC49189
(E/Z)-4-hydroxy Tamoxifen-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
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GC49124
EN219
EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.
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GC49084
PHY34
An inhibitor of late-stage autophagy
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GC49016
Dimethyl 2-ketoglutarate
An esterified form of α-ketoglutarate
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GC62637
AUTAC4
AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC).
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GC62630
TAS-117 hydrochloride
TAS-117 hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 hydrochloride induces apoptosis and autophagy.
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GC62626
ICCB-19 hydrochloride
ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor.
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GC62564
Mito-LND
Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells.
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GC62528
(Rac)-Hesperetin
(Rac)-Hesperetin is the racemate of Hesperetin.
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GC62465
Idelalisib D5
Idelalisib D5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor.
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GC62399
RA375
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead.
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GC62339
mTOR inhibitor-8
mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer. mTOR inhibitor-8 inhibits the activity of mTOR via FKBP12 and induces autophagy of A549 human lung cancer cells.
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GC62309
AS1708727
AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively.
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GC62239
Zetomipzomib
Zetomipzomib (KZR-616), a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome.
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GC62210
ONX-0914 TFA
ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome.
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GC62203
Falcarindiol
Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells.
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GC62193
(1S,2S)-Bortezomib
(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans.
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GC62146
XST-14
XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects.
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GC62135
BC1618
BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation).
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GC61945
PR-924
PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities.
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GC61865
Cearoin
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.
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GC19766
Heparin sodium salt (MW 15kDa)
A polymer of Heparin with the molecular weight of 15kD
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GC61809
Olanzapine D3
Olanzapine D3 (LY170053-d3) is the deuterium labeled Olanzapine.
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GC61669
Ethyl 3,4-dihydroxybenzoate
Ethyl 3,4-dihydroxybenzoate (Ethyl protocatechuate), an antioxidant, is a prolyl-hydroxylase inhibitor found in the testa of peanut seeds.
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GC61565
Indophagolin
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.
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GC61521
Calmodulin-Dependent Protein Kinase II(290-309) acetate
Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
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GC61520
Cilengitide TFA
Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively.
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GC61472
Zingiberene
Zingiberene (α-Zingiberene) is a monocyclic sesquiterpene which is the predominant constituent of ginger with oil content (Zingiber officinale). Neuroprotective potential. Zingiberene triggers autophagy. Anticancer activity.
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GC19729
Adenosine 5′-diphosphoribose sodium
Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite.
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GC48689
SBP-7455
A dual inhibitor of ULK1 and ULK2
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GC48676
Monascuspiloin
A fungal metabolite with anticancer activity
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GC48614
IMP-1710
A clickable UCH-L1 inhibitor
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GC48595
Chenodeoxycholic Acid MaxSpec® Standard
A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
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GC48410
VH 032 Linker 3 (hydrate)
A VHL ligand 1 derivative
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GC48406
PSI (trifluoroacetate salt)
A proteasome inhibitor
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GC19569
Hydroquinone
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GC48124
Tamoxifen-d5
An internal standard for the quantification of tamoxifen
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GC48118
Sunitinib-d10
An internal standard for the quantification of sunitinib
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GC48052
Rilmenidine-d4
An internal standard for the quantification of rilmenidine
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GC48027
Rapamycin-d3
An internal standard for the quantification of rapamycin
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GC47965
Pomalidomide-d5
An internal standard for the quantification of pomalidomide
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GC47735
N-acetyl Desethylchloroquine-d4
An internal standard for the quantification of N-acetyl desethylchloroquine
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GC47445
Hydroxychloroquine-d4 (sulfate)
An internal standard for the quantification of hydroxychloroquine
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GC47436
HT-2 Toxin-13C22
An internal standard for the quantification of HT-2 toxin