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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome

Products for  Ubiquitination/ Proteasome

  1. Cat.No. Product Name Information
  2. GC30761 α-Hydroxylinoleic acid α-Hydroxylinoleic acid (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. α-Hydroxylinoleic acid Chemical Structure
  3. GC46008 (±)-Thalidomide-d4

    N-Phthaloylglutamimide-d4

     An internal standard for the quantification of (±)-thalidomide (±)-Thalidomide-d4 Chemical Structure
  4. GC34960 (+)-Talarozole (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. (+)-Talarozole Chemical Structure
  5. GC10603 (-)-epicatechin gallate

    ECG

     major catechin in green tea (-)-epicatechin gallate Chemical Structure
  6. GC17242 (-)-epigallocatechin

    (-)EGC, epi-Gallocatechin, NSC 674039

     green tea epicatechin (-)-epigallocatechin Chemical Structure
  7. GC14049 (-)-Epigallocatechin gallate (EGCG)

    EGCG

     (-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis. (-)-Epigallocatechin gallate (EGCG) Chemical Structure
  8. GC40218 (-)-Epigallocatechin Gallate-d3/d4

    EGCG-d3/d4

     (-)-Epigallocatechin gallate-d3/d4 is intended for use as an internal standard for the quantification of (-)-epigallocatechin gallate by GC- or LC-MS. (-)-Epigallocatechin Gallate-d3/d4 Chemical Structure
  9. GC31386 (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively. (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) Chemical Structure
  10. GC65547 (1S,2R)-Alicapistat

    (1S,2R)-ABT-957

     (1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD). (1S,2R)-Alicapistat Chemical Structure
  11. GC62193 (1S,2S)-Bortezomib (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans. (1S,2S)-Bortezomib Chemical Structure
  12. GC60395 (3S,5R)-Fluvastatin D6

    (3S,5R)-XU 62-320 free acid D6

     (3S,5R)-Fluvastatin D6 is the deuterium labeled (3S,5R)-Fluvastatin sodium. (3S,5R)-Fluvastatin D6 Chemical Structure
  13. GC49189 (E/Z)-4-hydroxy Tamoxifen-d5

    Afimoxifene-d5, 4-OHT-d5

     An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen (E/Z)-4-hydroxy Tamoxifen-d5 Chemical Structure
  14. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (AT-101 (acetic acid)) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) Chemical Structure
  15. GC31665 (R)-BPO-27 (R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR?inhibitor with an?IC50 of 4 nM. (R)-BPO-27 Chemical Structure
  16. GC41233 (R)-MG132

    (R)-MG132 is a proteasome inhibitor with an IC50 of 100 nM.

     (R)-MG132 Chemical Structure
  17. GC62528 (Rac)-Hesperetin (Rac)-Hesperetin is the racemate of Hesperetin. (Rac)-Hesperetin Chemical Structure
  18. GC73075 (rel)-ML-SI3

    trans-ML-SI3

     (rel)-ML-SI3 is one of the active ingredients of ML-SI3 (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 Chemical Structure
  19. GC13136 (S)-Crizotinib Potent MTH1 inhibitor (S)-Crizotinib Chemical Structure
  20. GC14820 (S)-Naproxen

    CG 3117, (S)-Naproxen

     (S)-Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. (S)-Naproxen Chemical Structure
  21. GC15015 (±)-Bay K 8644

    SQ 28,873

     L-type Ca2+-channel activator (±)-Bay K 8644 Chemical Structure
  22. GC35068 1-Monomyristin

    MG(14:0/0:0/0:0), 1-Monomyristin

     A monoacylglycerol 1-Monomyristin Chemical Structure
  23. GC17295 10058-F4 10058-F4 is a c-Myc inhibitor that inhibits c-Myc-Max dimerization and prevents transcriptional activation of c-Myc target gene expression. 10058-F4 Chemical Structure
  24. GC14918 10074-G5 c-Myc inhibitor 10074-G5 Chemical Structure
  25. GC11720 17-AAG (KOS953)

    BMS 722782, CP 127374, KOS 953, NSC 330507, Tanespimycin

     17-AAG(Geldanamycin), a natural benzoquinone ansamycin antibiotic, is the first established inhibitor of Hsp90. 17-AAG (KOS953) Chemical Structure
  26. GC90818 2,3,7,8-Tetrachlorodibenzo-p-dioxin

    A toxicant and an agonist of AhR

     2,3,7,8-Tetrachlorodibenzo-p-dioxin Chemical Structure
  27. GC40947 2,3-Dimethoxy-5-methyl-p-benzoquinone

    Coenzyme Q0, CoQ0

     2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. 2,3-Dimethoxy-5-methyl-p-benzoquinone Chemical Structure
  28. GC46057 2,5-Dihydroxycinnamic Acid phenethyl ester An inhibitor of 5-LO 2,5-Dihydroxycinnamic Acid phenethyl ester Chemical Structure
  29. GC15084 2-Methoxyestradiol (2-MeOE2)

    2Hydroxyestradiol 2methyl ether, 2ME2, NSC 659853, Panzem

     2-Methoxyestradiol (2-MeOE2/2-Me) is an HIF-1α inhibitor. 2-Methoxyestradiol (2-MeOE2) Chemical Structure
  30. GC30011 20-Deoxyingenol A diterpenoid with antioxidant and osteoprotective activities 20-Deoxyingenol Chemical Structure
  31. GC68503 20S Proteasome activator 1

    20S Proteasome activator 1 is an effective activator of the 20S protease, with IC50 values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like sites, chymotrypsin-like sites and caspase-like sites respectively. It can be translated in cellular systems to prevent accumulation of pathogenic A53T mutant alpha-synuclein. 20S Proteasome activator 1 can be used for research on neurodegenerative diseases.

     20S Proteasome activator 1 Chemical Structure
  32. GC64472 20S Proteasome-IN-1 20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2. 20S Proteasome-IN-1 Chemical Structure
  33. GC35112 3'-Hydroxypterostilbene 3'-Hydroxypterostilbene is a Pterostilbene analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 ?M, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer. 3'-Hydroxypterostilbene Chemical Structure
  34. GC12791 3,3'-Diindolylmethane

    DIM

     A phytochemical with antiradiation and chemopreventative effects 3,3'-Diindolylmethane Chemical Structure
  35. GC74663 3,4-Dimethoxychalcone 3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone Chemical Structure
  36. GC10710 3-Methyladenine

    3-MA

    3-Methyladenine is a classic autophagy inhibitor.

     3-Methyladenine Chemical Structure
  37. GC32767 3BDO

    3-Benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one

     A butyrolactone derivative and autophagy inhibitor 3BDO Chemical Structure
  38. GC39658 4,4'-Dimethoxychalcone 4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties. 4,4'-Dimethoxychalcone Chemical Structure
  39. GC42414 4-hydroxy Tolbutamide 4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. 4-hydroxy Tolbutamide Chemical Structure
  40. GC35132 4-Hydroxylonchocarpin 4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin Chemical Structure
  41. GC70208 4-Hydroxytolbutamide-d9 4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide-d9 Chemical Structure
  42. GC13104 4E1RCat

    eIF4E/eIF4G Interaction Inhibitor II

     Dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction 4E1RCat Chemical Structure
  43. GC30785 4E2RCat 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM. 4E2RCat Chemical Structure
  44. GC10468 4EGI-1

    eIF4E/eIF4G Interaction Inhibitor

     Competitive eIF4E/eIF4G interaction inhibitor 4EGI-1 Chemical Structure
  45. GC25019 5-amino-2,4-dimethylpyridine (5A-DMP) 5-amino-2,4-dimethylpyridine (5A-DMP) Chemical Structure
  46. GC65668 5-Amino-8-hydroxyquinoline

    5A8HQ

     5-Amino-8-hydroxyquinoline (5A8HQ), a potential anticancer candidate, has promising proteasome inhibitory activity. 5-Amino-8-hydroxyquinoline Chemical Structure
  47. GC45356 5-Aminolevulinic Acid (hydrochloride)   5-Aminolevulinic Acid (hydrochloride) Chemical Structure
  48. GC10946 5-Azacytidine

    Antibiotic U 18496, 5AzaC, Ladakamycin, Mylosar, NSC 102816, NSC 103627, U 18496, WR 183027

     5-Azacytidine (also known as 5-AzaC), a compound belonging to a class of cytosine analogues, is a DNA methyl transferase (DNMT) inhibitor that exerts potent cytotoxicity against multiple myeloma (MM) cells, including MM.1S, MM.1R, RPMI-8266, RPMI-LR5, RPMI-Dox40 and Patient-derived MM, with the half maximal inhibition concentration IC50 values of 1.5 μmol/L, 0.7 μmol/L, 1.1 μmol/L, 2.5 μmol/L, 3.2 μmol/L and 1.5 μmol/L respectively. 5-Azacytidine Chemical Structure
  49. GN10241 5-Methoxypsoralen

    5-Methoxypsoralen, 5-MOP, Heraclin, NSC 95437

     5-Methoxypsoralen Chemical Structure
  50. GC72854 6-CEPN 6-CEPN is a RAS inhibitor. 6-CEPN Chemical Structure
  51. GC16267 6-Hydroxydopamine hydrobromide

    6-hydroxy Dopamine, Oxidopamine, 2,4,5-Trihydroxyphenethylamine

     6-Hydroxydopamine hydrobromide (6-OHDA) is a structural analogue of catecholamines, dopamine and noradrenaline, and exerts its toxic effects on catecholaminergic neurons. 6-Hydroxydopamine hydrobromide Chemical Structure
  52. GN10228 6-Shogaol

    A bioactive component of ginger

     6-Shogaol Chemical Structure
  53. GC91604 8RK64 8RK64 is a covalent inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50 = 0.32 µM) and a click chemistry reagent. 8RK64 Chemical Structure
  54. GC12739 A 484954 A eukaryotic elongation factor-2 (eEF-2) kinase inhibitor A 484954 Chemical Structure
  55. GC17710 A-317491

    A 317491;A317491

     A P2X3 and P2X2/3 receptor antagonist A-317491 Chemical Structure
  56. GC35211 A-317491 sodium salt hydrate A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 sodium salt hydrate Chemical Structure
  57. GC15014 A-867744 A positive allosteric modulator of α7 nAChRs A-867744 Chemical Structure
  58. GC11200 A23187

    Calcimycin

    A23187, free acid is a Ca2+ ionophore

     A23187 Chemical Structure
  59. GC42677 ABO (hydrochloride) ABO is a modulator of annexin A7. ABO (hydrochloride) Chemical Structure
  60. GC14069 ABT-199

    GDC 0199, Venetoclax

     Venetoclax (ABT-199, GDC-0199) is a selective inhibitor of Bcl-2 with a K i of 0.01 nM in cell-free assays. ABT-199 Chemical Structure
  61. GC17234 ABT-737

    ABT 737, ABT737

     An inhibitor of anti-apoptotic Bcl-2 proteins ABT-737 Chemical Structure
  62. GC15875 ABT-751 (E7010) ABT-751 (E7010)(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 (E7010) Chemical Structure
  63. GC12422 ABT-888 (Veliparib) ABT-888 (Veliparib) Chemical Structure
  64. GC10871 AC 55649 RARβ2 agonist, potent and selective AC 55649 Chemical Structure
  65. GC42685 Ac-ANW-AMC

    Ac-Ala-Asn-Trp-AMC

     Ac-ANW-AMC is a fluorescent substrate for the β5i (LMP7/PSMB8) subunit of the 20S immunoproteasome, with a maximum excitation wavelength of λEx=345nm and a maximum emission wavelength of λEm=445nm. Ac-ANW-AMC Chemical Structure
  66. GC46792 Ac-Nle-Pro-Nle-Asp-AMC (trifluoroacetate salt)

    Ac-Nle-Pro-Nle-Asp-7-amido-4-Methylcoumarin, Ac-nLPnLD-AMC

     A neuropeptide with diverse biological activities Ac-Nle-Pro-Nle-Asp-AMC (trifluoroacetate salt) Chemical Structure
  67. GC42710 Ac-PAL-AMC

    Acetyl-Pro-Ala-Leu-7-amino-4-Methylcoumarin, Ac-Pro-Ala-Leu-AMC

     Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. Ac-PAL-AMC Chemical Structure
  68. GC42712 Ac-RLR-AMC (trifluoroacetate salt)

    Ac-Arg-Leu-Arg-AMC, Ac-Arg-Leu-Arg-7-amino-4-Methylcoumarin

     Ac-RLR-AMC is a fluorogenic substrate for the 26S proteasome. Ac-RLR-AMC (trifluoroacetate salt) Chemical Structure
  69. GC42720 Ac-WLA-AMC

    Acetyl-Trp-Leu-Ala-7-amino-4-Methylcoumarin, Ac-Trp-Leu-Ala-AMC

     Ac-WLA-AMC is a fluorogenic substrate for the β5c subunit of the 20S proteasome. Ac-WLA-AMC Chemical Structure
  70. GC35228 Aceglutamide

    Aceglutamide, Acetylglutamine, N-acetyl Gln, NSC 186896

     Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration. Aceglutamide Chemical Structure
  71. GC11567 Acetazolamide

    L-579,486, NSC 145177

    carbonic anhydrase (CA) inhibitor

     Acetazolamide Chemical Structure
  72. GC14142 Acetylcholine Chloride

    ACh

     Major transmitter at many nervous sites Acetylcholine Chloride Chemical Structure
  73. GC17094 Acitretin

    all-trans Acitretin, Ro 10-1670, Ro 10-1670/000

    Metabolite of etretinate

     Acitretin Chemical Structure
  74. GC17113 Acitretin sodium Second-generation, systemic retinoid Acitretin sodium Chemical Structure
  75. GC10102 Aclacinomycin A

    NSC 208734

     An anthracycline with antibiotic and anticancer activities Aclacinomycin A Chemical Structure
  76. GC35238 Aclacinomycin A hydrochloride

    Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors.

     Aclacinomycin A hydrochloride Chemical Structure
  77. GC41242 Acridine Orange

    NSC 194350

    Acridine Orange is a cell-penetrating, nucleic acid-selective fluorescent dye.

     Acridine Orange Chemical Structure
  78. GC35242 Actein Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo. Actein Chemical Structure
  79. GC16866 Actinomycin D

    Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053, Oncostatin K

     Actinomycin D (dactinomycin) is a natural chromopeptide isolated from Streptomyces species, and has one heterocyclic chromophore and two cyclic pentapeptide lactone rings. [1] Actinomycin D Chemical Structure
  80. GC19019 Acumapimod

    BCT-197

     Acumapimod (BCT197) is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 uM for p38α. Acumapimod Chemical Structure
  81. GC10610 Adapalene

    CD 271

     RARβ and RARγ agonist Adapalene Chemical Structure
  82. GC14379 Adapalene sodium salt Retinoic acid receptor agonist Adapalene sodium salt Chemical Structure
  83. GC14106 Adenosine

    NSC 7652

     nucleoside Adenosine Chemical Structure
  84. GC19729 Adenosine 5′-diphosphoribose sodium

    ADP ribose sodium

     Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium Chemical Structure
  85. GC10707 Afatinib dimaleate

    Afatinib dimaleate, BIBW 2992, BIBW 2992MA2

     An inhibitor of EGFR and ErbB2 Afatinib dimaleate Chemical Structure
  86. GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib impurity 11 Chemical Structure
  87. GC35262 Afzelin

    Kaempferin, Kaempferol 3-O-rhamnoside, Kaempferol 3-O-α-L-rhamnopyranoside

     A polyphenolic glycoside flavone with diverse biological activities Afzelin Chemical Structure
  88. GC13697 AG-1024

    AGS 200, Tyrphostin AG1024

     AG-1024 is a reversible, competitive and selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 value of 7µM. AG-1024 can inhibit the phosphorylation of insulin receptor (IR) with an IC50 value of 57µM. AG-1024 Chemical Structure
  89. GC13854 AG-490 (Tyrphostin B42)

    Tyrphostin AG-490

     AG-490 (Tyrphostin B42) is EGFR inhibitor with IC50 of 0.1 µM, AG-490 also has an inhibitory effect on JAK2. AG-490 (Tyrphostin B42) Chemical Structure
  90. GC32817 AGN 193109 AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 Chemical Structure
  91. GC33315 AGN 194078 AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. AGN 194078 Chemical Structure
  92. GC12598 AGN 194310

    VTP-194310

     pan-RAR antagonist AGN 194310 Chemical Structure
  93. GC35265 AGN 195183

    IRX-5183; VTP-195183; NRX-195183

     AGN 195183 (IRX-5183) is a potent and selective agonist of RARα (Kd=3 nM) with improved binding selectivity relative to AGN 193836. AGN 195183 has no activity on RARβ/γ. AGN 195183 Chemical Structure
  94. GC35266 AGN 196996 AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). AGN 196996 Chemical Structure
  95. GC35267 AGN 205327 AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766/734/32 nM for RARα/β/γ respectively; no inhibition on RXR. AGN 205327 Chemical Structure
  96. GC35268 AGN 205728 AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ. AGN 205728 Chemical Structure
  97. GC10518 AICAR

    Acadesine, AICA-Riboside, NSC 105823

     AICAR (also called acadesine) is a purine nucleoside. AICAR Chemical Structure
  98. GC10580 AICAR phosphate AMPK activator AICAR phosphate Chemical Structure
  99. GC12646 AL 8697 p38α inhibitor,potent and selective AL 8697 Chemical Structure
  100. GC33743 Alicapistat (ABT-957)

    ABT-957

     Alicapistat (ABT-957) (ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD). Alicapistat (ABT-957) Chemical Structure
  101. GC15451 Aliskiren Aliskiren Chemical Structure

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