EBI2/GPR183

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

Products Related to EBI2/GPR183(7)

GC14433 7α,25-dihydroxy Cholesterol
CAS: 64907-22-8
Purity: >99.50%
A GPR183 agonist
GC15430 NIBR189
CAS: 1599432-08-2
Purity: >98.00%
EBI2 (GPR183) receptor antagonist
GC31651 GSK682753A
CAS: 1334294-76-6
Purity: >99.50%
GSK682753A is a selective and highly potent inverse agonist of the Epstein-Barr virus-induced receptor 2 (EBI2) with an IC 50 of 53.6nM. GSK682753A is commonly used in studies on EBI2/GPR183-related immune cell migration, B cell function, and inflammatory signaling.
GC38820 ML401
CAS: 1597489-14-9
Purity: >99.50%
ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM.
GC65986 SAE-14
CAS: 1241280-25-0
Purity: >98.00%
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC-induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
GC71487 GPR183 antagonist-2
CAS: 2924063-98-7
Purity: >99.00%
GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties.
GC74051 GPR183-IN-2
CAS: 2924064-10-6
Purity: >99.00%
GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC14433	7α,25-dihydroxy Cholesterol	64907-22-8	>99.50%
GC14433	A GPR183 agonist
GC15430	NIBR189	1599432-08-2	>98.00%
GC15430	EBI2 (GPR183) receptor antagonist
GC31651	GSK682753A	1334294-76-6	>99.50%
GC31651	GSK682753A is a selective and highly potent inverse agonist of the Epstein-Barr virus-induced receptor 2 (EBI2) with an IC 50 of 53.6nM. GSK682753A is commonly used in studies on EBI2/GPR183-related immune cell migration, B cell function, and inflammatory signaling.
GC38820	ML401	1597489-14-9	>99.50%
GC38820	ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM.
GC65986	SAE-14	1241280-25-0	>98.00%
GC65986	SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC-induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
GC71487	GPR183 antagonist-2	2924063-98-7	>99.00%
GC71487	GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties.
GC74051	GPR183-IN-2	2924064-10-6	>99.00%
GC74051	GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor.