Endocannabinoid/Endocannabinoid-like

Endogenous agonist for the GPR55 and CB1 receptors

N-Arachidonoyl Dopamine is a potent and selective endogenous CB1 receptor agonist with a Ki of 250 nM.

An endocannabinoid

Prostaglandin E1 ethanolamide (PGE1-EA) is the ethanolamine-amide analog of PGE1.

A stable analog of PGF 2α 2glyceryl ester

Polyunsaturated fatty acids such as arachidonate and linoeate, while essential to health maintenance, are subject to random peroxidation by ambient oxygen, resulting in fragmented and reactive decomposition products.

Synaptamide (Dehydroepiandrosteron(DHEA)) is an endogenous GPR110 (ADGRF1) ligand that stimulates cAMP production with an EC 50 value of 1.27nM.

R-2 methanandamide is a cannabinoid analog with a methyl group in the (R) configuration at C-2 of the ethanolamine group.

2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.

2-O-Hexadecyl Glycerol is a β-monoglyceride of palmitic acid.

N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities.

The glyceryl esters of arachidonic acid have been proposed as endogenous cannabinoid ligands.

Docosaenoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.

The endocannabinoids present a rich system of central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology that has stimulated research in many fields including memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation.

γ-Linolenoyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide.

The enzyme, fatty acid amide hydrolase (FAAH), is widely expressed in brain and other tissues, and is capable of hydrolyzing anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains.

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide.

MAGL Inhibitor Compound 23 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL Inhibitor Compound 23 exhibits anti-proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL Inhibitor Compound 23 blocks MAGL in cell-based as well as in vivo assays.

N-acylethanolamines (NAEs) are lipid-derived signaling compounds.

(±)17(18)-EpETE-Ethanolamide is an ω-3 endocannabinoid epoxide.

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate.

Palmitoyl ethanolamide (PEA) is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.

URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme.