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Filovirus

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Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).

The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.

Products Related to Filovirus(14)

  • GC14314 structure
    GC14314Aloperine
    CAS: 56293-29-9
    Purity: >98.00%

    An alkaloid

  • GC32089 structure
    GC32089Galidesivir hydrochloride (BCX 4430 (hydrochloride))
    CAS: 222631-44-9
    Purity: >99.50%

    Galidesivir (BCX4430) hydrochloride, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity.

  • GC32092 structure
    GC32092Galidesivir (BCX 4430)
    CAS: 249503-25-1
    Purity: >98.00%

    Galidesivir (BCX 4430) (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity.

  • GC43228 structure
    GC43228Cephaeline
    CAS: 483-17-0
    Purity: >98.00%

    Cephaeline is an alkaloid originally isolated from C.

  • GC67627 structure
    GC676272'-Deoxy-5'-O-DMT-2'-fluorouridine
    CAS: 146954-74-7
    Purity: >98%

    2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5'-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.

  • GC72368 structure
    GC72368Ansuvimab
    CAS: 2375952-29-5
    Purity: >99.00%

    Ansuvimab (Ansuvimab-zyk) is a recombinant human monoclonal IgG1 antibody that exhibits antiviral activity against Zaire ebolavirus.

  • GC72370 structure
    GC72370Atoltivimab
    CAS: 2135632-29-8
    Purity: >98.00%

    Atoltivimab (REGN3470), or maftivimab/odesivimab (Inmazeb) is the first Food and agent Administration (FDA)-approved monoclonal antibody to target Zaire ebolavirus (EBOVs) infection.

  • GC72421 structure
    GC72421Larcaviximab
    CAS: 1792982-56-9
    Purity: >96.00%

    Larcaviximab (c4G7-N) is an IgG1 kappa anti-Ebola virus glycoprotein chimeric monoclonal antibody.

  • GC72425 structure
    GC72425Maftivimab
    CAS: 2135632-36-7
    Purity: >96.00%

    Maftivimab (REGN3470-3471-3479), the inhibitor of Filovirus, is an Food and agent Administration (FDA)-approved agent.

  • GC72434 structure
    GC72434Odesivimab
    CAS: 2135632-30-1
    Purity: >99.00%

    Odesivimab is a human monoclonal antibody, targeting Ebola virus glycoprotein with a KD value of 7.74 nM for recombinant histidine-tagged Makona strain Ebola virus glycoprotein ectodomain protein.

  • GC72436 structure
    GC72436Porgaviximab
    CAS: 1792982-55-8
    Purity: 98.00%

    Porgaviximab is a monoclonal antibody that can be used Ebola infection research.

  • GC72446 structure
    GC72446Cosfroviximab
    CAS: 1792982-57-0
    Purity: 95.00%

    Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP).

  • GC72667 structure
    GC72667EBOV-IN-1
    CAS: 1335113-30-8
    Purity: >97.00%

    EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV).

  • GC78875 structure
    GC78875Antiviral agent 75
    CAS: 314035-79-5
    Purity: >98.00%

    Antiviral agent 75 (example D26) is a Ebolavirus ( EBOV ) and Bundibugyo ebolavirus (BDBV) inhibitor with IC 50 s of 0.11 μM and 0.75 μM, respectively.