FNC-TP |
| Catalog No.GC63541 |
FNC-TP is the intracellular active form of FNC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2457357-99-0
Sample solution is provided at 25 µL, 10mM.
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FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].
FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1].
FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1].
[1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2’-Deoxy-2’-β-fluoro-4’-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.
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