2,4-Dinitrobenzenesulfonic acid (Compound 3) is a ecto-5'-Nucleotidase ( CD73 ) inhibitor with a K i value of 63 μM for human and 144 μM for rat. 2,4-Dinitrobenzenesulfonic acid can inhibit the hydrolysis of adenosine monophosphate (AMP) to generate adenosine. 2,4-Dinitrobenzenesulfonic acid can be used for the research of cancer [1].
References:
[1]. Raza R, et al. Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors. Med Chem. 2012 Nov;8(6):1133-9.
References:
[1]. Raza R, et al. Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors. Med Chem. 2012 Nov;8(6):1133-9.