GLPBio

Albiglutide Fragment

Catalog No.: GC25046Purity:>98.00%
COASDSData Sheet
Albiglutide Fragment is the active fragment (7-36) of Albiglutide, a glucagon-like peptide-1 (GLP-1) mimetic belonging to the class of long-acting GLP-1 receptor agonists.

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Albiglutide Fragment
Cas No.: 782500-75-8
1mgIn Stock
$72.00
1
5mgIn Stock
$240.00
1
10mgIn Stock
$408.00
1
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

Description

Albiglutide Fragment is the active fragment (7-36) of Albiglutide, a glucagon-like peptide-1 (GLP-1) mimetic belonging to the class of long-acting GLP-1 receptor agonists. Albiglutide Fragment can be used in research related to type 2 diabetes (T2D)[1-4].

In vitro, RIN 1046-38 cells were co-treated with Albiglutide Fragment (10nM) and glucose (5mM) for 0.5-1 hours. Albiglutide Fragment significantly increased insulin secretion[5]. CA-77 cells were incubated with Albiglutide Fragment (0.01-10nM) in the presence of 2mM calcium for 2 hours. Albiglutide Fragment dose-dependently stimulated calcitonin secretion[6].

In vivo, traumatic brain injury (TBI) model rats received daily intracerebroventricular (i.c.v.) injections of Albiglutide Fragment (1nmol or 10nmol in 5μl) for 30 days. Albiglutide Fragment significantly improved neurological dysfunction and cognitive deficits after TBI[7]. NMRI mice received a single intravenous injection of Albiglutide Fragment (32nmol/kg). Albiglutide Fragment significantly reduced plasma glucose levels and increased plasma insulin levels in mice. When Albiglutide Fragment was combined with 2,5-AM, an additive hypoglycemic effect was produced[8].

References:
[1] Gil-Lozano M, Pérez-Tilve D, Alvarez-Crespo M, et al. GLP-1(7-36)-amide and Exendin-4 stimulate the HPA axis in rodents and humans. Endocrinology. 2010 Jun;151(6):2629-40.
[2] Chen M, Angeli FS, Shen YT, et al. GLP-1 (7-36) amide restores myocardial insulin sensitivity and prevents the progression of heart failure in senescent beagles. Cardiovasc Diabetol. 2014 Jul 31;13:115.
[3] Tang-Christensen M, Larsen PJ, Göke R, et al. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol. 1996 Oct;271(4 Pt 2):R848-56.
[4] Nilsson M, Bové KB, Suhrs E, et al. The effect of DPP-4-protected GLP-1 (7-36) on coronary microvascular function in obese adults. Int J Cardiol Heart Vasc. 2019 Jan 29;22:139-144.
[5] Doyle ME, Theodorakis MJ, Holloway HW, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8.
[6] Crespel A, De Boisvilliers F, Gros L, et al. Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line. Endocrinology. 1996 Sep;137(9):3674-80.
[7] Wang S, Liu A, Xu C, et al. GLP-1(7-36) protected against oxidative damage and neuronal apoptosis in the hippocampal CA region after traumatic brain injury by regulating ERK5/CREB. Mol Biol Rep. 2024 Feb 19;51(1):313.
[8] Ahrén B, Lindskog S, van Dijk G, et al. Effects of GLP-1 and 2,5-anhydro-D-mannitol on insulin secretion and plasma glucose in mice. Endocr Res. 1995 Aug;21(3):583-94.

Protocole (Protocol)

Cell experiment [1]:

Cell lines

RIN 1046-38 cells (rat insulinoma cell line) and CHO/GLP-1R cells (Chinese hamster ovary cells stably transfected with the human GLP-1 receptor)

Preparation Method

RIN 1046-38 cells were routinely cultured in M199 with Earle's salts supplemented with glucose (11mM), penicillin (50U/ml), streptomycin (50ug/ml), and glutamine (2mM) in a humidified 5% CO₂-95% air incubator at 37°C. CHO/GLP-1R cells were grown to confluency on plates. For insulin secretion assay, RIN 1046-38 cells were incubated with Albiglutide Fragment (10nM) and glucose (5mM) for 1h at 37°C. For cAMP determination, RIN 1046-38 cells were incubated with Albiglutide Fragment (10nM) and IBMX (1mM) for 0.5h at 37°C.

Reaction Conditions

10nM; 0.5-1h

Applications

Albiglutide Fragment significantly increased insulin secretion from RIN 1046-38 cells, approximately 2-fold above basal levels. In cAMP assays using RIN 1046-38 cells, Albiglutide Fragment induced intracellular cAMP production.

Animal experiment [2]:

Animal models

Male Sprague-Dawley (SD) rats (10-12 weeks old, weighing approximately 250g) subjected to traumatic brain injury (TBI)

Preparation Method

A severe TBI model was established via a controlled cortical impact. Immediately after TBI, rats received Albiglutide Fragment (1nmol or 10nmol in 5μl) intervention via intracerebroventricular (i.c.v.) injection once a day for 30 days.

Dosage form

1nmol or 10nmol in 5μl; i.c.v.; once daily for 30 days

Applications

Albiglutide Fragment significantly improved neurological dysfunction and cognitive deficits, reduced cerebral edema, decreased the levels of H₂O₂ and intracellular ROS, increased cellular antioxidant factors (CAT, SOD, GSH), promoted the activation of the ERK5/CREB signaling pathways, and suppressed apoptosis (reduced CC-3 and Bax/Bcl-2 expression) in the hippocampal tissues of TBI rats.

References:
[1] Doyle ME, Theodorakis MJ, Holloway HW, et al. The importance of the nine-amino acid C-terminal sequence of exendin-4 for binding to the GLP-1 receptor and for biological activity. Regul Pept. 2003 Jul 15;114(2-3):153-8.
[2] Wang S, Liu A, Xu C, et al. GLP-1(7-36) protected against oxidative damage and neuronal apoptosis in the hippocampal CA region after traumatic brain injury by regulating ERK5/CREB. Mol Biol Rep. 2024 Feb 19;51(1):313.

Documents produit (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Propriétés chimiques (Chemical Properties)

N° CAS
782500-75-8
Formule moléculaire
C148H224N40O45
Masse moléculaire
3283.6
Solubilité
Water: 100 mg/mL (30.45 mM);
Conservation
Store at -20°C
Conseils généraux
Choisissez un solvant adapté selon les données de solubilité du produit. Après préparation, répartissez la solution mère en aliquotes afin d’éviter les cycles répétés de congélation-décongélation.
Utilisez les solutions mères dans les 6 mois si elles sont conservées à -80°C, ou dans le mois si elles sont conservées à -20°C.
Pour améliorer la solubilité, réchauffez le tube à 37°C et soniquez-le pendant une durée appropriée.
Conditions d’expédition
Les échantillons d’évaluation sont expédiés avec des blocs réfrigérants. Les autres formats sont expédiés à température ambiante ou, sur demande, avec des blocs réfrigérants.

Calculateurs (Calculators)Molarité / Dilution / Masse moléculaire / Conversion d’unités / Formulation in vivo / Solubilité

g/mol

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