GLPBio

Anti-CD33 Antibody (OR000283)

Catalog No.: GC79442Purity:>99.00%Synonyms: ORM-6151 Antibody; BMS-986497 Antibody
COASDSData Sheet
Anti-CD33 Antibody (OR000283) (ORM-6151 Antibody; BMS-986497 Antibody) is an antibody targeting CD33.

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Anti-CD33 Antibody (OR000283)
1mgIn Stock
$180.00
1
5mgIn Stock
$504.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

Anti-CD33 Antibody (OR000283) (ORM-6151 Antibody; BMS-986497 Antibody) is an antibody targeting CD33. It is generated by grafting the FAb (H&L) sequence of Gemtuzumab onto an IgG1 Fc carrying the N297A mutation, which inhibits Fc-γR binding. Anti-CD33 Antibody (OR000283) can be used to construct degrader-antibody conjugates (DACs), such as ORM-6151 [1] [2].

In Vitro, Anti-CD33 Antibody (OR000283) conjugated to the GSPT1 degrader SMol006 (BMS-986497/ORM-6151) potently kills CD33-expressing AML cell lines and primary relapsed/refractory AML patient blasts with picomolar potency, while showing minimal toxicity to non-cancerous hematopoietic progenitor cells[2].

References:
[1]. Palacino J, et al. ORM-6151: a first-in-class, anti-CD33 antibody-enabled GSPT1 degrader for AML.
[2]. Izzo D, et al. Innovative payloads for ADCs in cancer treatment: moving beyond the selective delivery of chemotherapy. Ther Adv Med Oncol. 2025;17:17588359241309461. Published 2025 Jan 2.

Documents produit (Product Documents)

Purity:>99.00%Appearance:A liquid
COASDSData Sheet

Propriétés chimiques (Chemical Properties)

Synonymes
ORM-6151 Antibody; BMS-986497 Antibody
Masse moléculaire
145.49
Conservation
Store at -20°C
Conditions d’expédition
Les échantillons d’évaluation sont expédiés avec des blocs réfrigérants. Les autres formats sont expédiés à température ambiante ou, sur demande, avec des blocs réfrigérants.

Calculateurs (Calculators)Molarité / Dilution / Masse moléculaire / Conversion d’unités / Formulation in vivo / Solubilité

g/mol

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