Atherosclerosis

Lysophosphatidylcholines constitue une classe importante de molécules de phospholipides, qui est le produit de l'hydrolyse de la phosphatidylcholine par la phospholipase A2.

Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.

MMP-8 Inhibitor I est un puissant inhibiteur de la métalloprotéinase matricielle 8 (MMP-8) avec une faible biodisponibilité orale.

Graphislactone A is an antioxidant produced by Cephalosporium IFB-E001 and M.

Cholesteryl heptadecanoate is a cholesterol ester (CE) formed by the condensation of cholesterol with heptadecanoic acid, a C-17 saturated fatty acid that does not occur in any natural animal or vegetable fat at high concentrations.

9(S)-HODE is produced by the lipoxygenation of linoleic acid in both plants and animals.

ETC-1002 (ESP-55016) est un nouvel agent hypolipémiant oral à prise quotidien qui inhibe la critrate lyase adénosine triphosphate (ACL), une enzyme de la voie de synthèse du cholestérol, et entraîne une augmentation de la régulation des récepteurs du cholestérol des lipoprotéines de basse densité (LDL), avec une demi-vie comprise entre 15 et 24 heures.

5α,6α-epoxy Cholestanol est un dérivé du cholestérol qui peut être généré par voie de catalyse par le système d'enzyme cytochrome P450 dans les mitochondries ou peut être induit lors de la peroxydation des lipides. 5α,6α-epoxy Cholestanol peut réguler la biosynthèse des acides biliaires et induire la différenciation et la mort des cellules tumorales.

Lactosylceramide (LacCer) is an endogenous bioactive sphingolipid.

7α-hydroxy Cholesterol-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS.

Cholesterol-d6 is intended for use as an internal standard for the quantification of cholesterol by GC- or LC-MS.

5β,6β-epoxy Cholestanol is an oxidative metabolite of cholesterol that is formed via radical and non-radical oxidation of cholesterol at the 5,6-double bond.

(±)11-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid.

Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.

Le 24-déhydrocholestérol est une molécule similaire au cholestérol.

The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall.

(±)13-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.

(±)9-HODE cholesteryl ester was originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.

13(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.

13(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.

13(S)-HOTrE is the 15-lipoxygenase (15-LO) product of linolenic acid.

4-hydroxy Nonenal (4-HNE) is a major aldehyde produced during the lipid peroxidation of ω-6 polyunsaturated fatty acids, such as arachidonic acid and linoleic acid.

9(R)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions.